细菌化学感受器的系统发育和蛋白质序列分析

Phylogenetic and Protein Sequence Analysis of Bacterial Chemoreceptors.

作者信息

Ortega Davi R, Zhulin Igor B

机构信息

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.

Computer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, TN, USA.

出版信息

Methods Mol Biol. 2018;1729:373-385. doi: 10.1007/978-1-4939-7577-8_29.

DOI:10.1007/978-1-4939-7577-8_29

PMID:29429105

Abstract

Identifying chemoreceptors in sequenced bacterial genomes, revealing their domain architecture, inferring their evolutionary relationships, and comparing them to chemoreceptors of known function become important steps in genome annotation and chemotaxis research. Here, we describe bioinformatics procedures that enable such analyses, using two closely related bacterial genomes as examples.

摘要

在已测序的细菌基因组中识别化学感受器，揭示其结构域架构，推断其进化关系，并将它们与已知功能的化学感受器进行比较，已成为基因组注释和趋化性研究中的重要步骤。在此，我们以两个密切相关的细菌基因组为例，描述了能够进行此类分析的生物信息学程序。