肠白塞病患者的癌症风险：一项全国基于人群的研究。
Cancer Risk in Patients with Intestinal Behçet's Disease: A Nationwide Population-Based Study.
机构信息
Department of Public Health, Graduate School, Yonsei University, Seoul, Korea.
Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
出版信息
Gut Liver. 2018 Jul 15;12(4):433-439. doi: 10.5009/gnl17324.
BACKGROUND/AIMS: The relationship between intestinal Behçet's disease (BD) and cancer remains unclear. We conducted a nationwide, population-based study to determine the risk of cancer in patients with intestinal BD.
METHODS
Using the National Health Insurance claims records, we collected data on 365 patients who had been diagnosed with intestinal BD between 2011 and 2014. Standardized incidence ratios (SIRs) of overall and site-specific cancers in patients with intestinal BD in comparison with the general population were calculated.
RESULTS
Among 167 men with intestinal BD, four cases of cancer were observed; among 191 women with BD, eight cases of cancer were observed. The risk of all cancers was significantly higher in women with intestinal BD than in women of the general population (SIR, 4.27; 95% confidence interval [CI], 1.84 to 8.41). However, in men with intestinal BD, the risk of all cancers was not significantly higher than that in men of the general population (SIR, 2.08; 95% CI, 0.57 to 5.33). The risk of hematologic cancer was significantly higher in both men and women with intestinal BD than in their counterparts in the general population (SIR, 23.90; 95% CI, 2.89 to 86.32 in men; SIR, 34.47; 95% CI, 4.17 to 124.51 in women). In particular, patients with intestinal BD showed a higher risk of leukemia and myelodysplastic syndrome than the general population.
CONCLUSIONS
Patients with intestinal BD demonstrated a higher risk of hematologic cancer, especially leukemia, than the general population. Furthermore, women with intestinal BD showed a higher risk of all cancers.
背景/目的：肠型贝赫切特病（BD）与癌症之间的关系仍不清楚。我们进行了一项全国性的基于人群的研究，以确定肠型 BD 患者发生癌症的风险。
方法
我们使用国家健康保险索赔记录，收集了 2011 年至 2014 年间被诊断为肠型 BD 的 365 名患者的数据。计算了肠型 BD 患者的总体和特定部位癌症的标准化发病比（SIR），并与一般人群进行比较。
结果
在 167 名男性肠型 BD 患者中，观察到 4 例癌症；在 191 名女性 BD 患者中，观察到 8 例癌症。女性肠型 BD 患者的所有癌症风险明显高于一般人群（SIR，4.27；95%置信区间[CI]，1.84 至 8.41）。然而，男性肠型 BD 患者的所有癌症风险并不明显高于一般人群（SIR，2.08；95%CI，0.57 至 5.33）。肠型 BD 患者的血液系统癌症风险明显高于一般人群中的相应患者（SIR，23.90；95%CI，2.89 至 86.32 男性；SIR，34.47；95%CI，4.17 至 124.51 女性）。特别是，肠型 BD 患者发生白血病和骨髓增生异常综合征的风险高于一般人群。
结论
肠型 BD 患者发生血液系统癌症的风险高于一般人群，特别是白血病。此外，肠型 BD 女性患者的所有癌症风险更高。
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