[Assessment of renal function with intravoxel incoherent motion and diffusion tensor imaging in type 2 diabetic patients].

To evaluate the application value of intravoxel incoherent motion (IVIM) and diffusion tensor imaging (DTI) in detecting early-stage diabetic nephropathy and to assess the damage of ralated renal function. A total of 52 patients with type 2 diabetes diagnosed in Zhongda Hospital were collected from April 2016 to May 2017 and were assigned to DM group (diabetes without nephropathy, =32) and DN group (diabetes with nephropathy, =20) according to detection of microalbuminuria, a cohort of healthy recipients were included as control group (=27) in the meantime. All of the subjects underwent IVIM and DTI examination. The cortical and medullary parameters[IVIM: perfusion fraction f, tissue diffusivity D, pseudodiffuvisity D(*;) DTI: fractional anisotropy FA, apparent diffusion coefficient ADC, principal diffusivities (λ1, λ2, λ3)]were obtained respectively and were compared among groups. The relationship between MRI related parameters and estimated glomerular filtration rate (eGFR) were statistically investigated; and diagnostic performance of IVIM and DTI in discriminating DM and DN group was evaluated by receiver operating characteristic analysis. The cortical and medullary f, D values in DN group were lower than those in DM group and control group (=17.32, 15.69, 6.71, 10.94, all <0.05). D values of all subjects showed positive correlations with eGFR (cortex =0.518, medulla =0.538, both <0.05). The diagnostic efficiency of cortical f values to discriminate diabetes and diabetic nephropathy was 0.817, the cut-off value was 0.205. The medullary FA value in DM group was lower than that in control group ((0.371±0.051 vs 0.423±0.043, =4.188, <0.05); and the medullary FA value in DN group (0.315±0.062) was lower than that in control and DM group (=25.08, <0.05). The medullary λ3 values in DM group and DN group were all significantly higher than that in control group (=7.86, <0.05). The diagnostic efficiency of medullary FA values to discriminate diabetes and diabetic nephropathy was 0.763, the cut-off value was 0.344. IVIM and DTI can reflect the abnormal perfusion and diffusion during early-stage diabetic nephropathy and have the potential value to assess the damage of ralated renal function.