Zhang Y, Niu M, Li Y, Wang J, Qu B, Zheng C X, Huang P, Yu W H
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Zhonghua Yi Xue Za Zhi. 2018 Feb 6;98(6):440-444. doi: 10.3760/cma.j.issn.0376-2491.2018.06.009.
To analyze the prevalence and risk factors of diabetic retinopathy (DR) in ophthalmic patients. A cross-sectional study was performed. Diabetic patients who were admitted to Department of Ophthalmology, Traditional Chinese Medicine Hospital of Muping between October 2012 and June 2013 were included. General information and medical history were obtained from each subject by questionaires. Laboratory and detailed ophthalmic examinations were performed during the study. DR was diagnosed and graded by mydriatic fundus photography. Prevalence of DR was calculated and logistic regression was used to analyze the relationship between DR and various factors. A total of 676 diabetic patients were included, and 455 of them presented with DR at a morbidity rate of 67.31%. Among DR patients, the number of mild, moderate, severe non-proliferative diabetic retinopathy (NPDR) patients and proliferative diabetic retinopathy (PDR) patients were 211 (46.37%), 167 (36.70%), 57 (12.53%) and 20 (4.40%), respectively. There was no significant difference in the prevalence of DR among different age groups (χ(2)=6.527, =0.089). However, there was a significant difference between different disease duration groups (χ(2)=39.401, <0.001), as well as between insulin therapy group and non-insulin therapy group (χ(2)=7.378, =0.007). The multivariate logistic regression analysis demonstrated the independent risk factors for DR occurrence were hemoglobin A1c (HbA1c) (=1.131, 95%: 1.022-1.252, =0.011) and duration of diabetes (=1.077, 95%: 1.046-1.108, <0.001). The prevalence of DR in ophthalmic patients was associated with duration of diabetes, HbA1c, obesity, smoke, nephropaty and insulin therapy. Increased HbA1c level and longer duration of diabetes were independent risk factors for DR in diabetic patients.
分析眼科患者糖尿病视网膜病变（DR）的患病率及危险因素。进行了一项横断面研究。纳入2012年10月至2013年6月期间在牟平区中医医院眼科住院的糖尿病患者。通过问卷调查获取每位受试者的一般信息和病史。在研究期间进行实验室检查和详细的眼科检查。通过散瞳眼底照相诊断并分级DR。计算DR的患病率，并采用逻辑回归分析DR与各种因素之间的关系。共纳入676例糖尿病患者，其中455例患有DR，患病率为67.31%。在DR患者中，轻度、中度、重度非增殖性糖尿病视网膜病变（NPDR）患者和增殖性糖尿病视网膜病变（PDR）患者的数量分别为211例（46.37%）、167例（36.70%）、57例（12.53%）和20例（4.40%）。不同年龄组DR患病率差异无统计学意义（χ(2)=6.527，P =0.089）。然而，不同病程组之间差异有统计学意义（χ(2)=39.401，P<0.001），胰岛素治疗组和非胰岛素治疗组之间差异也有统计学意义（χ(2)=7.378，P =0.007）。多因素逻辑回归分析显示，DR发生的独立危险因素为糖化血红蛋白（HbA1c）（β=1.131，95%CI：1.022 - 1.252，P =0.011）和糖尿病病程（β=1.077，95%CI：1.046 -
