基因和基因多态性与华南地区人群肺和脊柱结核易感性的关系。
Polymorphisms in the and Gene and Susceptibility to Pulmonary and Spinal Tuberculosis among Southern Chinese Population.
机构信息
Department of Laboratory Medicine, The People's Hospital of Guangxi Autonomous Region, Nanning, China.
Department of Pharmacy, The People's Hospital of Guangxi Autonomous Region, Nanning, China.
出版信息
Dis Markers. 2017;2017:4590235. doi: 10.1155/2017/4590235. Epub 2017 Dec 21.
OBJECTIVE
To investigate the association of single-nucleotide polymorphisms (SNPs) in gene and gene among pulmonary TB (PTB) and spinal TB (STB) patients.
METHODS
In a total of 190 PTB patients, 183 STB patients were enrolled as the case group and 362 healthy individuals at the same geographical region as the control group. The SNPs (rs722555 and rs1135791) and the promoter -308G>A (rs1800629) and -238G>A (rs361525) polymorphisms in were genotyped. - -238G>A polymorphism was involved in susceptibility to STB, but not to PTB. The - -238 A allele was a protective factor against STB (A versus G: OR [95% CI] = 0.331 [0.113-0.972], = 0.044). Furthermore, the presence of the -238 A allele was considered a trend to decrease the risk of STB (AG versus GG: = 0.062, OR [95% CI] = 0.352 [0.118-1.053]; AA + AG versus GG: = 0.050, OR [95CI%] = 0.335 [0.113-0.999]). However, SNPs (rs722555 and rs1135791) and -308G>A (rs1800629) showed no association with PTB and STB in all genetic models.
CONCLUSION
The -238 A allele appeared a protective effect against STB, whereas the SNPs (rs722555 and rs1135791) and -308G>A (rs1800629) showed no association with susceptibility to PTB and STB patients in southern China.
目的
探讨基因和基因中单核苷酸多态性（SNPs）与肺结核（PTB）和脊柱结核（STB）患者的相关性。
方法
共纳入 190 例 PTB 患者、183 例 STB 患者作为病例组，同一地理区域的 362 例健康个体作为对照组。基因中的 SNPs（rs722555 和 rs1135791）和启动子-308G>A（rs1800629）和-238G>A（rs361525）多态性进行了基因分型。- -238G>A 多态性与 STB 的易感性有关，但与 PTB 无关。- -238A 等位基因是 STB 的保护因素（A 对 G：比值比[95%可信区间] = 0.331[0.113-0.972]，=0.044）。此外，-238A 等位基因的存在被认为是降低 STB 风险的趋势（AG 对 GG：=0.062，比值比[95%可信区间] = 0.352[0.118-1.053]；AA+AG 对 GG：=0.050，比值比[95%CI%] = 0.335[0.113-0.999]）。然而，rs722555 和 rs1135791 基因的 SNPs 以及-308G>A（rs1800629）在所有遗传模型中均与 PTB 和 STB 无关。
结论
-238A 等位基因对 STB 有保护作用，而 rs722555 和 rs1135791 基因的 SNPs 以及-308G>A（rs1800629）与中国南方人群中 PTB 和 STB 患者的易感性无关。
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