Fareed J, Walenga J M, Baker W H, Hayes A, Hoppensteadt D A
Semin Thromb Hemost. 1986 Apr;12(2):102-9. doi: 10.1055/s-2007-1003542.
Molecular markers of hemostatic activation provide a reliable measure of the endogenous pathophysiologic state in atherosclerosis. Measurement of these markers before and after exercise provides a diagnostic probe for cellular-vascular interactions in patients with atherosclerosis. Molecular markers may possibly identify very early stages of atherosclerosis due to their inherent sensitivity. A high-risk cardiovascular population can be easily recognized by profiling molecular markers of hemostatic activation. Newly developed immunoassays can be used to quantitate these markers in routine laboratories. Additional clinical studies are needed to establish the diagnostic role of these molecular markers in patients with atherosclerosis and related disorders.
止血激活的分子标志物为动脉粥样硬化内源性病理生理状态提供了可靠的衡量指标。运动前后对这些标志物的测量为动脉粥样硬化患者的细胞 - 血管相互作用提供了一种诊断性检测手段。由于其固有的敏感性，分子标志物可能识别出动脉粥样硬化的极早期阶段。通过分析止血激活的分子标志物，能够轻易识别出心血管高危人群。新开发的免疫测定法可用于常规实验室对这些标志物进行定量分析。还需要更多临床研究来确立这些分子标志物在动脉粥样硬化及相关疾病患者中的诊断作用。
