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长期结肠支架通畅性用于治疗合并贝伐单抗的梗阻性结直肠癌

Long-Term Colon Stent Patency for Obstructing Colorectal Cancer Combined with Bevacizumab.

作者信息

Latenstein Anouk E J, Hendriks Mathijs P, van Halsema Emo E, van Hooft Jeanin E, van Berkel Anne-Marie

机构信息

Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Department of Medical Oncology, Northwest Clinics, Alkmaar, The Netherlands.

出版信息

Case Rep Gastroenterol. 2017 Nov 29;11(3):711-717. doi: 10.1159/000481933. eCollection 2017 Sep-Dec.

DOI:10.1159/000481933
PMID:29430222
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5803727/
Abstract

Self-expanding metal stents can be considered as initial treatment for malignant large bowel obstruction in the palliative setting. It is suggested that systemic anti-angiogenic therapy increases the risk of stent perforation. We report a 65-year-old woman with a metastatic, obstructing colon tumor who has been successfully treated with stent placement and chemoimmunotherapy consisting of capecitabine and bevacizumab for 8 years.

摘要

自膨式金属支架可被视为姑息治疗中恶性大肠梗阻的初始治疗方法。有研究表明，全身抗血管生成治疗会增加支架穿孔的风险。我们报告了一名65岁患有转移性梗阻性结肠肿瘤的女性患者，她成功接受了支架置入术，并接受了由卡培他滨和贝伐单抗组成的化疗免疫治疗，已持续8年。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e55/5803727/0dade66d8ba0/crg-0011-0711-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e55/5803727/0dade66d8ba0/crg-0011-0711-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e55/5803727/0dade66d8ba0/crg-0011-0711-g01.jpg

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Efficacy and safety of bevacizumab plus chemotherapy compared to chemotherapy alone in previously untreated advanced or metastatic colorectal cancer: a systematic review and meta-analysis.与单纯化疗相比，贝伐单抗联合化疗用于既往未治疗的晚期或转移性结直肠癌的疗效和安全性：一项系统评价和荟萃分析。
BMC Cancer. 2016 Aug 24;16(1):677. doi: 10.1186/s12885-016-2734-y.
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Colonic perforation with intraluminal stents and bevacizumab in advanced colorectal cancer: retrospective case series and literature review.晚期结直肠癌中结肠穿孔与腔内支架及贝伐单抗：回顾性病例系列研究与文献综述
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Global cancer statistics, 2012.
全球癌症统计数据，2012 年。
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Self-expandable metal stents for obstructing colonic and extracolonic cancer: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline.用于阻塞性结直肠癌和结外癌的自膨式金属支架：欧洲胃肠内镜学会（ESGE）临床指南
Endoscopy. 2014 Nov;46(11):990-1053. doi: 10.1055/s-0034-1390700. Epub 2014 Oct 17.
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Perforation in colorectal stenting: a meta-analysis and a search for risk factors.结直肠支架置入后穿孔：荟萃分析及危险因素探寻。
Gastrointest Endosc. 2014 Jun;79(6):970-82.e7; quiz 983.e2, 983.e5. doi: 10.1016/j.gie.2013.11.038. Epub 2014 Mar 18.
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Dig Liver Dis. 2014 Jun;46(6):561-7. doi: 10.1016/j.dld.2014.02.006. Epub 2014 Mar 14.
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