Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing, 100049, China.
Adv Healthc Mater. 2018 May;7(10):e1701123. doi: 10.1002/adhm.201701123. Epub 2018 Feb 12.
In this work, a novel ruthenium complex loaded monolayer layered double hydroxide (LDH) (denoted as Ru(C-bpy) /mLDH) as supramolecular nanosensor is synthesized, which is greatly exclusive to the hypoxic tumor microenvironment. The Ru(C-bpy) /mLDH ultrathin sheet displays not only enhanced luminescence lifetime compared to the parent Ru(C-bpy) alone, but also improved oxygen responsibility under an excitation of 488 or 800 nm. Moreover, the Ru(C-bpy) /mLDH is possessed of two-photon fluorescence imaging ability under the 800 nm irradiation. In addition, the Ru(C-bpy) /mLDH can generate singlet oxygen with a high yield (φ ) of 0.28 under the 520 nm irradiation, while the φ of Ru(C-bpy) is 0.19. Therefore, the Ru(C-bpy) /mLDH can be applied as a supramolecular theranostic agent with light-switchable cancer imaging and photodynamic therapy properties.
在这项工作中，合成了一种新型负载钌配合物的单层层状双氢氧化物（LDH）（表示为 Ru(C-bpy)/mLDH）作为超分子纳米传感器，对缺氧肿瘤微环境具有很强的排他性。与单独的母体 Ru(C-bpy) 相比，Ru(C-bpy)/mLDH 超薄片不仅显示出增强的荧光寿命，而且在 488 或 800nm 的激发下提高了氧的响应性。此外，Ru(C-bpy)/mLDH 在 800nm 照射下具有双光子荧光成像能力。此外，在 520nm 照射下，Ru(C-bpy)/mLDH 可以产生具有高量子产率（φ）的单线态氧（0.28），而 Ru(C-bpy) 的φ为 0.19。因此，Ru(C-bpy)/mLDH 可用作具有光开关癌症成像和光动力治疗性能的超分子治疗剂。
