Reitan J A, Porter W, Braunstein M
Anesth Analg. 1986 Sep;65(9):933-7.
In two groups of 31 healthy patients undergoing minor elective surgery, anesthesia was induced intravenously with either midazolam maleate, 0.2 mg/kg, or thiopental, 3.5 mg/kg. All subjects received 2 micrograms/kg fentanyl 5 min before the induction agents. Induction time with midazolam was significantly longer than with thiopental (97.1 +/- 10.9 sec vs 59.4 +/- 5.0 sec) and time to orientation postoperatively was significantly longer after midazolam (31.7 +/- 4.2 min vs 11.0 +/- 1.1 min). Continued recovery after orientation, measured by a series of psychomotor tests, was also significantly longer with midazolam than with thiopental. Anterograde amnesia was evident in 84.8% of the midazolam treated patients and in only 31.4% of the thiopental group. This degree of absence of recall was acknowledged positively by the affected patients. The protracted recovery period may limit the use of midazolam in short surgical procedures.
在两组31名接受小型择期手术的健康患者中，分别静脉注射0.2毫克/千克马来酸咪达唑仑或3.5毫克/千克硫喷妥钠诱导麻醉。所有受试者在诱导药物注射前5分钟接受2微克/千克芬太尼。咪达唑仑的诱导时间明显长于硫喷妥钠（97.1±10.9秒对59.4±5.0秒），术后定向时间在使用咪达唑仑后也明显更长（31.7±4.2分钟对11.0±1.1分钟）。通过一系列心理运动测试测量，定向后持续恢复时间咪达唑仑组也明显长于硫喷妥钠组。84.8%接受咪达唑仑治疗的患者出现顺行性遗忘，而硫喷妥钠组仅为31.4%。受影响患者对这种无回忆程度给予了肯定评价。较长的恢复期可能会限制咪达唑仑在短手术中的应用。
