Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
J Steroid Biochem Mol Biol. 2018 Jun;180:23-28. doi: 10.1016/j.jsbmb.2018.02.002. Epub 2018 Feb 9.
Vitamin D deficiency is rampant in the Middle East, even in children and adolescents. This study was designed to investigate the effects of different vitamin D repletion strategies commonly used on serum vitamin D levels of Saudi adolescents.
A 6-month multi-center, controlled, clinical study, involving 34 schools in the central region of Riyadh, Saudi Arabia. Different strategies of vitamin D supplementation were tested (200 ml fortified milk of different brands or vitamin D tablet (1,000IU). Anthropometrics were taken and fasting blood samples withdrawn at baseline and after intervention for the quantification of serum glucose, lipid profile and 25(OH) vitamin D. A significant increase in 25(OH)D level was observed in subjects supplemented with vitamin D tablet, milk brand 2 and milk brand 4, whereas subjects supplied with fortified milk brands 1 and 3 respectively, exhibited a significant decrease in 25(OH)D levels. Analysis of covariance showed that after adjusting for baseline 25(OH)D, age, gender and BMI, the mean 25(OH)D levels of children who were taking vitamin D tablet (9.1 ± 0.8 nmol/l) and milk brand 4 were significantly higher (7.3 ± 1.1 nmol/l) than children taking milk brand 2 (1.6 ± 1.0 nmol/l). Subjects supplied with milk brands 1 and 2 exhibited a significant increase in total cholesterol level, while it dropped significantly in subjects taking milk brand 3, while no changes were observed in other groups. Different strategies in vitamin D supplementation used in this clinical study elicited varying degrees of improvement in serum 25(OH)D level. The observed outcomes were dependent on the strategy and gender in the Saudi adolescent population, with oral tablet supplementation being favored in boys.
维生素 D 缺乏在中东地区十分普遍，甚至在儿童和青少年中也是如此。本研究旨在调查在沙特青少年中常用的不同维生素 D 补充策略对血清维生素 D 水平的影响。
一项为期 6 个月的多中心、对照、临床研究，涉及沙特利雅得中部地区的 34 所学校。测试了不同的维生素 D 补充策略（不同品牌的强化牛奶 200ml 或维生素 D 片剂（1000IU）。在基线和干预后测量人体测量学和空腹血样，以定量检测血清葡萄糖、血脂谱和 25(OH)维生素 D。补充维生素 D 片剂、牛奶品牌 2 和牛奶品牌 4 的受试者 25(OH)D 水平显著升高，而分别补充强化牛奶品牌 1 和 3 的受试者 25(OH)D 水平显著降低。协方差分析显示，在调整基线 25(OH)D、年龄、性别和 BMI 后，服用维生素 D 片剂的儿童（9.1±0.8 nmol/L）和牛奶品牌 4 的平均 25(OH)D 水平显著更高（7.3±1.1 nmol/L）比服用牛奶品牌 2 的儿童（1.6±1.0 nmol/L）。服用牛奶品牌 1 和 2 的受试者总胆固醇水平显著升高，而服用牛奶品牌 3 的受试者总胆固醇水平显著降低，而其他组则没有变化。本临床研究中使用的不同维生素 D 补充策略在血清 25(OH)D 水平上引起了不同程度的改善。观察到的结果取决于沙特青少年人群的策略和性别，口服片剂补充在男孩中更为有利。
