滤泡状甲状腺癌与许特莱细胞癌患者临床特征的比较。

Comparison of clinical characteristics of patients with follicular thyroid carcinoma and Hürthle cell carcinoma.

作者信息

Ernaga Lorea Ander, Migueliz Bermejo Iranzu, Anda Apiñániz Emma, Pineda Arribas Javier, Toni García Marta, Martínez de Esteban Juan Pablo, Insausti Serrano Ana María

机构信息

Servicio de Endocrinología y Nutrición, Complejo Hospitalario de Navarra, Pamplona, Navarra, España.

出版信息

Endocrinol Diabetes Nutr (Engl Ed). 2018 Mar;65(3):136-142. doi: 10.1016/j.endinu.2017.12.006. Epub 2018 Feb 9.

DOI:10.1016/j.endinu.2017.12.006

PMID:29433918

Abstract

INTRODUCTION

Hürthle cell carcinoma (HCC) is an uncommon thyroid cancer historically considered to be a variant of follicular thyroid carcinoma (FTC). The aim of this study was to assess the differences between these groups in terms of clinical factors and prognoses.

PATIENTS AND METHODS

A total of 230 patients (153 with FTC and 77 with HCC) with a median follow-up of 13.4 years were studied. The different characteristics were compared using SPSS version 20 statistical software.

RESULTS

Patients with HCC were older (57.3±13.8 years vs. 44.6±15.2 years; P<.001). More advanced TNM stages were also seen in patients with HCC and a greater trend to distant metastases were also seen in patients with HCC (7.8% vs. 2.7%, P=.078). The persistence/recurrence rate at the end of follow-up was higher in patients with HCC (13% vs. 3.9%, P=.011). However, in a multivariate analysis, only age (hazard ratio [HR] 1.10, confidence interval [CI] 1.04-1.17; P=.001), size (HR 1.43, CI 1.05-1.94; P=.021), and histological subtype (HR 9.79, CI 2.35-40.81; P=.002), but not presence of HCC, were significantly associated to prognosis.

CONCLUSION

HCC is diagnosed in older patients and in more advanced stages as compared to FTC. However, when age, size, and histological subtype are similar, disease-free survival is also similar in both groups.

摘要

引言

许特莱细胞癌（HCC）是一种罕见的甲状腺癌，历史上被认为是滤泡状甲状腺癌（FTC）的一种变体。本研究的目的是评估这些组在临床因素和预后方面的差异。

患者与方法

共研究了230例患者（153例FTC患者和77例HCC患者），中位随访时间为13.4年。使用SPSS 20版统计软件比较不同特征。

结果

HCC患者年龄较大（57.3±13.8岁 vs. 44.6±15.2岁；P<.001）。HCC患者也有更多的晚期TNM分期，并且HCC患者有更高的远处转移趋势（7.8% vs. 2.7%，P=.078）。随访结束时，HCC患者的持续/复发率更高（13% vs. 3.9%，P=.011）。然而，在多变量分析中，只有年龄（风险比[HR] 1.10，置信区间[CI] 1.04-1.17；P=.001）、大小（HR 1.43，CI 1.05-1.94；P=.021）和组织学亚型（HR 9.79，CI 2.35-40.81；P=.002）与预后显著相关，而HCC的存在与否与预后无关。