子宫和阴道黏膜的免疫学。
Immunology of the Uterine and Vaginal Mucosae.
机构信息
Departments of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA; Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA; Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Detroit, MI 48201, USA.
Division of Infectious Disease, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA; Perinatal Institute, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA.
出版信息
Trends Immunol. 2018 Apr;39(4):302-314. doi: 10.1016/j.it.2018.01.007. Epub 2018 Feb 9.
Along with the maintenance of symbiotic mutualism with commensal microbes and protection against invasive infections common to all mucosal barrier tissues, female reproductive tissues have additional, unique tasks that include dynamic cyclic cellular turnover in menstruation and immunological tolerance to genetically foreign fetal antigens in pregnancy. Here we review current knowledge on distinct features of the immune cells in female reproductive tissue with regard to antimicrobial host defense and adaptations to accommodate the fetus during pregnancy. Outstanding areas for future research to obtain new functional insights on this enigmatic mucosal barrier are also highlighted.
除了与共生微生物保持共生互惠关系和抵御所有黏膜屏障组织共有的侵袭性感染外，女性生殖组织还有其他独特的任务，包括月经期间动态循环的细胞更新和妊娠期间对遗传上异体胎儿抗原的免疫耐受。在这里，我们综述了女性生殖组织中免疫细胞在抗微生物宿主防御和适应妊娠期间容纳胎儿方面的独特特征的现有知识。我们还强调了未来研究的突出领域，以获得对这一神秘黏膜屏障的新功能见解。
Zotero 插件