Berard Alicia R, Brubaker Douglas K, Nemecio Dalí X, Farr Zuend Christina
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Department of Pathology, Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA.
Am J Reprod Immunol. 2025 Feb;93(2):e70035. doi: 10.1111/aji.70035.
Infertility, defined as the inability to establish a clinical pregnancy after a year of regular, unprotected sexual intercourse, impacts 8%-12% of couples worldwide. Many of these couples turn to in vitro fertilization (IVF) to build their families. The success rate of IVF procedures is variable, with estimates of up to 40% of embryo transfers being unsuccessful. Herein we review the existing literature on the role of the female and male urogenital microbiomes and genital inflammation on fertility and IVF outcomes. We discuss the microbiome across the female reproductive tract (FRT) and identify associations with female infertility, female genital tract inflammation, and success of IVF procedures. We also discuss the male urogenital microbiome and the associations between microbial taxa, genital inflammation, and male fertility parameters. Finally, we consider microbial transfer within couples and the impact this may have on fertility and the success of IVF procedures.
不孕症被定义为在规律、无保护的性交一年后仍无法实现临床妊娠，全球有8% - 12%的夫妇受其影响。这些夫妇中的许多人会求助于体外受精（IVF）来组建家庭。IVF程序的成功率各不相同，据估计高达40%的胚胎移植会失败。在此，我们综述了关于女性和男性泌尿生殖微生物群以及生殖器炎症对生育能力和IVF结果影响的现有文献。我们讨论了整个女性生殖道（FRT）的微生物群，并确定其与女性不孕症、女性生殖道炎症以及IVF程序成功率之间的关联。我们还讨论了男性泌尿生殖微生物群以及微生物分类群、生殖器炎症和男性生育参数之间的关联。最后，我们考虑夫妻间的微生物传播及其对生育能力和IVF程序成功率可能产生的影响。
