Peng Qian, Deng Zhiyuan, Pan Hao, Gu Liqun, Liu Ousheng, Tang Zhangui
Xiangya Stomatological Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Oncol Lett. 2018 Feb;15(2):1379-1388. doi: 10.3892/ol.2017.7491. Epub 2017 Nov 24.
The mitogen-activated protein kinase (MAPK) signaling pathway is associated with tumor cell proliferation, differentiation, apoptosis, angiogenesis, invasion and metastasis. The present review assesses the involvement of the MAPK signaling pathway in oral cancer progression and invasion based on analysis of individual sub-pathways and their mechanisms of action. The regulation of this pathway for targeted oral cancer therapy is explored and the challenges confronting this, as well as corresponding potential solutions, are discussed. Exploring this pathway with an emphasis on its components, subfamilies, sub-pathways, interactions with other pathways and clinical practice modes may improve oral cancer treatment.
丝裂原活化蛋白激酶（MAPK）信号通路与肿瘤细胞的增殖、分化、凋亡、血管生成、侵袭和转移相关。本综述基于对各个子通路及其作用机制的分析，评估MAPK信号通路在口腔癌进展和侵袭中的作用。探讨了该通路用于口腔癌靶向治疗的调控，并讨论了面临的挑战以及相应的潜在解决方案。着重从其组成成分、亚家族、子通路、与其他通路的相互作用以及临床实践模式等方面探索该通路，可能会改善口腔癌的治疗效果。
