Cao Junhua, An Qi, Wang Lei
Department of Pediatric Internal Medicine, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China.
Oncol Lett. 2018 Feb;15(2):1397-1402. doi: 10.3892/ol.2017.7467. Epub 2017 Nov 21.
Sarcomas arise from primitive mesenchymal cells, which are classified, into two main groups: Bone and soft tissue sarcomas. We have searched all-important electronic databases including Google scholar and PubMed for the collection of latest literature pertaining to pediatric sarcomas. Latest literature confirmed that these tumors are relatively rare and represent only 1% of all malignancies but they have higher incidence in children. Pediatric sarcomas comprise about 13% of all pediatric malignancies and are ranked third in childhood cancers. The highest incidence rates are reported among rhabdomyosarcoma, osteosarcoma and Ewing's sarcomas in children. All of these neoplasms often display highly aggressive behavior with tendency to form metastases. Important globally used management avenues include surgery with systemic chemotherapy and have success rate of 70% at 5-years. Furthermore, in the cases of advanced stages, the prognosis is poor, chances of treatment failure and recurrence are quite high. Utilization of cancer stem cells is the latest approach with great potential in management of above pathological state. The present review article discuss all-important aspects of commonly found pediatric sarcomas throughout the world.
肉瘤起源于原始间充质细胞，可分为两大类：骨肉瘤和软组织肉瘤。我们检索了所有重要的电子数据库，包括谷歌学术和PubMed，以收集有关小儿肉瘤的最新文献。最新文献证实，这些肿瘤相对罕见，仅占所有恶性肿瘤的1%，但在儿童中的发病率较高。小儿肉瘤约占所有小儿恶性肿瘤的13%，在儿童癌症中排名第三。据报道，儿童横纹肌肉瘤、骨肉瘤和尤因肉瘤的发病率最高。所有这些肿瘤通常表现出高度侵袭性的行为，并有形成转移的倾向。全球常用的重要治疗方法包括手术加全身化疗，5年成功率为70%。此外，在晚期病例中，预后较差，治疗失败和复发的几率相当高。利用癌症干细胞是治疗上述病理状态的最新方法，具有很大的潜力。本综述文章讨论了全球常见的小儿肉瘤的所有重要方面。
