Asghar S S, Dingemans K P, Kammeijer A, Faber W R, Abdel Mawla M Y
Complement. 1986;3(1):40-8. doi: 10.1159/000467876.
Certain complement inhibitors, namely chlorpromazine, suramin, 2-hydroxystilbamidine and chlorophenothiazine sulphonate were tested for their ability to suppress complement deposition and vascular injury at the site of an Arthus reaction. Deposition of complement was suppressed in the order 2-hydroxystilbamidine greater than suramin greater than chlorpromazine. All the above mentioned four compounds strongly protected vascular injury as observed by electron microscopic studies. At Arthus reaction sites prepared without drug treatment venules ranged from normal to severely altered and damaged. Discontinuities in endothelial linings varied from small to longer stretches. In the latter situation remaining endothelial cells were degenerated and endothelial remnants did not have an intact basal lamina. After treatment with the above complement inhibitors, at arthus reaction sites some venules appeared normal, whereas others were altered but in all cases the endothelium and its basal lamina remained intact.
对某些补体抑制剂，即氯丙嗪、苏拉明、2-羟基二脒基苯和氯吩噻嗪磺酸盐，进行了测试，以考察它们抑制Arthus反应部位补体沉积和血管损伤的能力。补体沉积的抑制程度依次为：2-羟基二脒基苯＞苏拉明＞氯丙嗪。电子显微镜研究表明，上述四种化合物均能强烈保护血管免受损伤。在未经药物处理的Arthus反应部位，小静脉从正常到严重改变和受损不等。内皮衬里的不连续性从小段到较长段不等。在后一种情况下，剩余的内皮细胞发生退化，内皮残余物没有完整的基底层。用上述补体抑制剂处理后，在Arthus反应部位，一些小静脉看起来正常，而另一些则有改变，但在所有情况下，内皮及其基底层均保持完整。
