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[肿瘤学中高剂量静脉注射地塞米松治疗的皮肤感觉异常]

[Cutaneous paresthesia in high-dose intravenous dexamethasone therapy in oncology].

作者信息

Rasche H, Meier C R, Schneider J, Gröticke J, Schönhöfer P

出版信息

Dtsch Med Wochenschr. 1986 Sep 12;111(37):1406-7. doi: 10.1055/s-2008-1068642.

DOI:10.1055/s-2008-1068642
PMID:2943576
Abstract

Seventeen oncological patients reported unpleasant but clinically harmless skin sensations directly after intravenous injection of dexamethasone, persisting for 2-4 minutes. In 16 cases, these paraesthesias (tingling, burning, itching, twinging) occurred in the genital or perineal area. In one case, the symptoms started in this area and then extended over the entire truncus integument for a short period. The cause of this obviously drug-induced side effect is unknown.

摘要

17名肿瘤患者在静脉注射地塞米松后直接报告了不愉快但临床上无害的皮肤感觉,持续2至4分钟。16例中,这些感觉异常(刺痛、灼痛、瘙痒、刺痛)出现在生殖器或会阴区域。1例中,症状始于该区域,然后在短时间内扩展至整个躯干皮肤。这种明显由药物引起的副作用的原因尚不清楚。

相似文献

1
[Cutaneous paresthesia in high-dose intravenous dexamethasone therapy in oncology].[肿瘤学中高剂量静脉注射地塞米松治疗的皮肤感觉异常]
Dtsch Med Wochenschr. 1986 Sep 12;111(37):1406-7. doi: 10.1055/s-2008-1068642.
2
[Intravenous dexamethasone treatment].
Dtsch Med Wochenschr. 1987 Apr 3;112(14):570.
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Paresthesia from cutaneous exposure to a synthetic pyrethroid insecticide.皮肤接触合成拟除虫菊酯类杀虫剂引起的感觉异常。
Arch Dermatol. 1984 Jun;120(6):744-6.
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An uncommon adverse effect following bolus administration of intravenous dexamethasone.
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Combination therapy with thalidomide and dexamethasone in patients with newly diagnosed multiple myeloma not undergoing upfront autologous stem cell transplantation: a phase II trial.沙利度胺与地塞米松联合治疗新诊断的未接受前期自体干细胞移植的多发性骨髓瘤患者:一项II期试验。
Haematologica. 2005 Dec;90(12):1650-4.
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Antiemetic efficacy of high-dose intravenous metoclopramide and dexamethasone in patients receiving cisplatin-based chemotherapy: a randomized controlled trial.
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A phase I/II study of paclitaxel plus cisplatin as first-line therapy for head and neck cancers: preliminary results.一项关于紫杉醇联合顺铂作为头颈部癌一线治疗的I/II期研究:初步结果。
Semin Oncol. 1995 Dec;22(6 Suppl 15):50-4.
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[Ultra-high, short-term dexamethasone therapy in craniocerebral trauma. Rationale and design of a multicenter study].[超短期大剂量地塞米松治疗颅脑创伤。一项多中心研究的理论依据与设计]
Neurochirurgia (Stuttg). 1989 Jul;32(4):93-100. doi: 10.1055/s-2008-1054013.
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Dexamethasone plus ondansetron for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a comparison with dexamethasone alone.地塞米松联合昂丹司琼预防腹腔镜胆囊切除术患者术后恶心呕吐:与单用 地塞米松的比较
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Diffuse cutaneous hypersensitivity reaction after dexamethasone/polymyxin B/neomycin combination eyedrops.地塞米松/多粘菌素B/新霉素复方眼药水引起的弥漫性皮肤过敏反应。
Ann Ophthalmol. 1986 Mar;18(3):95-6.

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