a Department of Clinical and Health Psychology, College of Public Health and Health Professions , University of Florida , Gainesville , FL , United States.
b Department of Biostatistics, College of Public Health and Health Professions and College of Medicine , University of Florida , Gainesville , FL , United States.
Aging Ment Health. 2019 Apr;23(4):515-523. doi: 10.1080/13607863.2018.1430740. Epub 2018 Feb 13.
Antiretroviral therapy is affording longer lifespans for people living with HIV (PLWH), yet factors such as substance use play an increasing role in morbidity and mortality in this population. Though previous studies have examined substance use differences between age cohorts of PLWH, no study has examined the influence of birth cohort on current substance use patterns. Thus, this study investigated the prevalence of past 12-month self-reported substance use between four birth cohorts, <1970 (M age = 54.1), 1970s (M age = 41.5), 1980s (M age = 31.3 years old), and 1990s (M age = 23.2 years old) of PLWH in Florida.
PLWH (N = 934) recruited from community health clinics in Florida completed a questionnaire assessing sociodemographics, health status, and substance use. Multivariate logistic regressions utilizing the <1970 cohort as the referent group examined the relationship between birth cohort and substance use.
The 1980s cohort had significantly greater odds of marijuana use compared to the oldest cohort (<1970s), while the three younger cohorts (1970s, 1980s, and 1990s) evidenced a significantly greater odds of ecstasy use compared to the oldest group. Contrastingly, the three younger birth cohorts reported significantly less crack use than the oldest cohort, while the youngest group (1990s) also demonstrated an 80% reduction in injection drug use compared to the oldest group.
The older cohort evidenced significantly greater crack and injection drug use, while the younger cohorts evidenced greater marijuana and ecstasy use. Therefore, it is important to develop age-specific substance use interventions among PLWH.
抗逆转录病毒疗法为感染艾滋病毒的人（PLWH）提供了更长的寿命，但物质使用等因素在该人群的发病率和死亡率中起着越来越重要的作用。尽管先前的研究已经检查了 PLWH 年龄队列之间的物质使用差异，但没有研究检查出生队列对当前物质使用模式的影响。因此，本研究调查了佛罗里达州四个出生队列（<1970 年（M 年龄= 54.1）、1970 年代（M 年龄= 41.5）、1980 年代（M 年龄= 31.3 岁）和 1990 年代（M 年龄= 23.2 岁）的 PLWH 在过去 12 个月内自我报告的物质使用的流行率。
从佛罗里达州社区健康诊所招募的 PLWH（N = 934）完成了一份问卷，评估了社会人口统计学、健康状况和物质使用情况。利用<1970 年队列作为参考组的多变量逻辑回归检查了出生队列与物质使用之间的关系。
与最年长的队列（<1970 年代）相比，1980 年代队列使用大麻的可能性显著增加，而三个较年轻的队列（1970 年代、1980 年代和 1990 年代）使用摇头丸的可能性显著增加与最年长的组相比。相比之下，三个较年轻的出生队列报告的可卡因使用量明显少于最年长的队列，而最年轻的队列（1990 年代）与最年长的队列相比，注射吸毒的减少了 80%。
年长的队列表现出明显更高的可卡因和注射吸毒率，而年轻的队列则表现出更高的大麻和摇头丸使用率。因此，为 PLWH 制定特定年龄的物质使用干预措施非常重要。
