Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Department of Radiology, PLA 101st Hospital, Wuxi Jiangsu, China.
J Magn Reson Imaging. 2018 Aug;48(2):459-468. doi: 10.1002/jmri.25977. Epub 2018 Feb 13.
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has been shown to be a promising technique for assessing lung lesions. However, DCE-MRI often suffers from motion artifacts and insufficient imaging speed. Therefore, highly accelerated free-breathing DCE-MRI is of clinical interest for lung exams.
To test the performance of rapid free-breathing DCE-MRI for simultaneous qualitative and quantitative assessment of pulmonary lesions using Golden-angle RAdial Sparse Parallel (GRASP) imaging.
Prospective.
Twenty-six patients (17 males, mean age = 55.1 ± 14.4) with known pulmonary lesions.
FIELD STRENGTH/SEQUENCE: 3T MR scanner; a prototype fat-saturated, T -weighted stack-of-stars golden-angle radial sequence for data acquisition and a Cartesian breath-hold volumetric-interpolated examination (BH-VIBE) sequence for comparison.
After a dual-mode GRASP reconstruction, one with 3-second temporal resolution (3s-GRASP) and the other with 15-second temporal resolution (15s-GRASP), all GRASP and BH-VIBE images were pooled together for blind assessment by two experienced radiologists, who independently scored the overall image quality, lesion delineation, overall artifact level, and diagnostic confidence of each case. Perfusion analysis was performed for the 3s-GRASP images using a Tofts model to generate the volume transfer coefficient (K ) and interstitial volume (V ).
Nonparametric paired two-tailed Wilcoxon signed-rank test; Cohen's kappa; unpaired Student's t-test.
15s-GRASP achieved comparable image quality with conventional BH-VIBE (P > 0.05), except for the higher overall artifact level in the precontrast phase (P = 0.018). The K and V in inflammation were higher than those in malignant lesions (K : 0.78 ± 0.52 min vs. 0.37 ± 0.22 min , P = 0.020; V : 0.36 ± 0.16 vs. 0.26 ± 0.1, P = 0.177). Also, the K and V in malignant lesions were also higher than those in benign lesions (K : 0.37 ± 0.22 min vs. 0.04 ± 0.04 min , P = 0.001; V : 0.26 ± 0.12 vs. 0.10 ± 0.00, P = 0.063).
This feasibility study demonstrated the performance of high spatiotemporal resolution free-breathing DCE-MRI of the lung using GRASP for qualitative and quantitative assessment of pulmonary lesions.
2 Technical Efficacy: Stage 1 J. MAGN. RESON. IMAGING 2018;48:459-468.
动态对比增强磁共振成像（DCE-MRI）已被证明是一种有前途的技术，可用于评估肺部病变。然而，DCE-MRI 通常会受到运动伪影和成像速度不足的影响。因此，临床对用于肺部检查的高加速自由呼吸 DCE-MRI 很感兴趣。
使用 Golden-angle RAdial Sparse Parallel（GRASP）成像来测试快速自由呼吸 DCE-MRI 对肺病变进行定性和定量评估的性能。
前瞻性。
26 名（17 名男性，平均年龄=55.1±14.4）已知患有肺部病变的患者。
磁场强度/序列：3T 磁共振扫描仪；用于数据采集的原型脂肪饱和 T1 加权星形金角径向序列和用于比较的笛卡尔屏气容积内插检查（BH-VIBE）序列。
在进行双模式 GRASP 重建后，一个具有 3 秒时间分辨率（3s-GRASP），另一个具有 15 秒时间分辨率（15s-GRASP），所有 GRASP 和 BH-VIBE 图像都被汇集在一起，由两名经验丰富的放射科医生进行盲法评估，他们独立对每个病例的整体图像质量、病变描绘、整体伪影水平和诊断信心进行评分。使用 Tofts 模型对 3s-GRASP 图像进行灌注分析，以生成体积转移系数（K）和间质体积（V）。
非参数配对双侧 Wilcoxon 符号秩检验；Cohen's kappa；未配对学生 t 检验。
15s-GRASP 与传统 BH-VIBE 相比获得了相当的图像质量（P＞0.05），但在对比前阶段的整体伪影水平更高（P=0.018）。炎症中的 K 和 V 值高于恶性病变（K：0.78±0.52min vs. 0.37±0.22min，P=0.020；V：0.36±0.16 vs. 0.26±0.1，P=0.177）。此外，恶性病变中的 K 和 V 值也高于良性病变（K：0.37±0.22min vs. 0.04±0.04min，P=0.001；V：0.26±0.12 vs. 0.10±0.00，P=0.063）。
这项可行性研究证明了使用 GRASP 进行高时空分辨率自由呼吸肺部 DCE-MRI 定性和定量评估肺部病变的性能。
2 技术功效：第 1 阶段 J. MAGN. RESON. IMAGING 2018；48：459-468。
