Buchin P J, Levy J S, Schullinger J N
J Clin Gastroenterol. 1986 Apr;8(2):111-4. doi: 10.1097/00004836-198604000-00002.
Gastrointestinal (GI) abnormalities are frequent in patients with Down's syndrome. In a 12-year retrospective review, we identified 187 patients with Down's syndrome admitted to the Columbia-Presbyterian Medical Center. Twenty-seven had major GI disorders, the most common being duodenal stenosis (DS, nine), gastroesophageal reflux (GER, five), imperforate anus (five), and Hirschsprung's disease (four). The mortality for the whole group was 11% (20 patients). The mortality in the small group of patients with duodenal stenosis was particularly high (five out of nine, or 56%). Associated congenital heart disease, especially endocardial cushion defects, and the frequent occurrence of pneumonia contributed to this high mortality rate.
唐氏综合征患者常出现胃肠道（GI）异常。在一项为期12年的回顾性研究中，我们确定了187名入住哥伦比亚长老会医学中心的唐氏综合征患者。27人患有严重的胃肠道疾病，最常见的是十二指肠狭窄（DS，9例）、胃食管反流（GER，5例）、肛门闭锁（5例）和先天性巨结肠（4例）。整个组的死亡率为11%（20例患者）。十二指肠狭窄患者小群体的死亡率特别高（9例中有5例，即56%）。相关的先天性心脏病，尤其是心内膜垫缺损，以及肺炎的频繁发生导致了这种高死亡率。
