Leyden J J, McGinley K J, Foglia A N
J Invest Dermatol. 1986 Apr;86(4):390-3. doi: 10.1111/1523-1747.ep12285658.
Quantitative cultures in 40 patients treated with systemic isotretinoin demonstrated a significant reduction in the anaerobic diphtheroid, Propionibacterium acnes within one month of therapy and a continued suppression during 5 months of treatment. This reduction persisted after discontinuation of isotretinoin therapy despite a return of sebum excretion to pretreatment levels. Surface aerobic bacteria showed a significant reduction in the total number of organisms and significant qualitative changes. Gram negative bacteria were sharply reduced in both the anterior nares and skin while Staphylococcus aureus recovery increased significantly.
对40例接受系统性异维甲酸治疗的患者进行的定量培养显示，治疗1个月内厌氧类白喉杆菌——痤疮丙酸杆菌显著减少，且在5个月的治疗期间持续受到抑制。尽管皮脂分泌恢复到治疗前水平，但异维甲酸治疗停止后这种减少仍持续存在。表面需氧菌的生物体总数显著减少，且有显著的定性变化。革兰氏阴性菌在前鼻孔和皮肤中均大幅减少，而金黄色葡萄球菌的恢复则显著增加。
