Zuniga J R, Knigge K K, Joseph S A
J Oral Maxillofac Surg. 1986 Sep;44(9):714-8.
To explore the hypothesis that nitrous oxide stimulates the beta-endorphin system in vivo, rats were exposed to nitrous oxide/oxygen at variable concentrations for one hour. beta-Endorphin concentration at sites along the neuraxis functionally involved with analgesia was elevated in nitrous oxide-exposed animals. The increase in beta-endorphin concentration was statistically significant at nitrous oxide concentrations of 60 and 80%. This elevation of beta-endorphin levels depended on the concentration of nitrous oxide delivered rather than on the duration of exposure. With cessation of nitrous oxide anesthesia, beta-endorphin concentration returned to control levels within 30 minutes.
为了探究一氧化二氮在体内刺激β-内啡肽系统的假说，将大鼠暴露于不同浓度的一氧化二氮/氧气环境中一小时。在一氧化二氮暴露组动物中，沿神经轴与镇痛功能相关部位的β-内啡肽浓度升高。在一氧化二氮浓度为60%和80%时，β-内啡肽浓度的增加具有统计学意义。β-内啡肽水平的升高取决于所输送的一氧化二氮浓度，而非暴露时间。停止一氧化二氮麻醉后，β-内啡肽浓度在30分钟内恢复到对照水平。
