可乐定对大鼠胃损伤的预防或增强作用
Gastric lesion-preventing or -potentiating activity of clonidine in rats.
作者信息
Del Soldato P
出版信息
Jpn J Pharmacol. 1986 Jun;41(2):257-9. doi: 10.1254/jjp.41.257.
PMID:2943923
Abstract
The dual effects of clonidine on gastric experimental damage have been studied in the rat. At lower doses, clonidine prevents gastric lesions induced by oxotremorine plus neostigmine, probably through an alpha 2-agonist mechanism; at higher doses, the compound potentiates dimaprit-induced gastric damage, probably through an H2-agonist mechanism.
摘要
已在大鼠中研究了可乐定对胃实验性损伤的双重作用。在较低剂量时，可乐定可能通过α2-激动剂机制预防由氧化震颤素加新斯的明诱导的胃损伤；在较高剂量时，该化合物可能通过H2-激动剂机制增强地马普利诱导的胃损伤。
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