CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience , National Center for Nanoscience and Technology of China , Beijing 100190 , P. R. China.
University of Chinese Academy of Sciences , Beijing 100049 , P. R. China.
ACS Appl Mater Interfaces. 2018 Mar 7;10(9):7871-7881. doi: 10.1021/acsami.8b00583. Epub 2018 Feb 23.
Mild acidic environment and angiogenesis are two typical characteristics of tumor. The specific response toward both lower pH and angiogenesis may enhance the targeting ability both for drug and diagnostic probe delivery. Herein, we present a kind of dual responding self-assembled nanotransformation material that is tumor angiogenesis targeting and pH triggered based on amphiphilic conjugation between peptides (STP) and aromatic molecules (tetraphenylethylene (TPE)). The morphology of the self-assembled peptide conjugates is responsibly changed from nanoparticles in neutral condition to nanofibers in acidic condition, which "turn on" the in vivo targeting imaging and accelerate the efficient drug delivery and in vivo therapy. On the basis of the well-controlled nanotransformation both in vitro and in vivo, we envisioned the successful demonstration of the responding materials would open a new avenue in turn on targeting imaging diagnostics and specific cancer therapeutics.
弱酸性环境和血管生成是肿瘤的两个典型特征。对较低 pH 值和血管生成的特定反应可能会增强药物和诊断探针输送的靶向能力。在这里，我们提出了一种双重响应的自组装纳米转化材料，该材料基于肽（STP）和芳香族分子（四苯乙烯（TPE））之间的两亲性缀合，是一种针对肿瘤血管生成和 pH 值的靶向材料。自组装肽缀合物的形态负责地从中性条件下的纳米颗粒转变为酸性条件下的纳米纤维，从而“开启”体内靶向成像，并加速有效的药物输送和体内治疗。基于体外和体内对纳米转化的良好控制，我们设想响应材料的成功演示将为靶向成像诊断和特定癌症治疗开辟新途径。
