内镜手术治疗鼻咽癌放疗后迟发性鼻-鼻窦并发症：主观结果。
Endoscopic Surgery for Delayed Sinonasal Complications of Radiation Therapy for Nasopharyngeal Carcinoma: A Subjective Outcome.
机构信息
Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Otorhinolaryngology Head and Neck Surgery, Chaim Sheba Medical Center, Tel HaShomer, Israel.
出版信息
Int J Radiat Oncol Biol Phys. 2018 Apr 1;100(5):1222-1227. doi: 10.1016/j.ijrobp.2018.01.014. Epub 2018 Jan 9.
PURPOSE
Delayed sinonasal complications of radiation therapy include choanal stenosis, osteoradionecrosis, chronic sinusitis, and intranasal synechiae. Only sporadic cases on their surgical treatment have been reported, with equivocal results.
METHODS AND MATERIALS
We performed a prospective case series of all patients who had been surgically treated for delayed sinonasal complications of radiation therapy in our institution during the past 10 years. The inclusion criteria required ≥6 months of follow-up after surgery. The included patients were asked to complete a Sino-Nasal Outcome Test 16-item questionnaire preoperatively and 6 months after surgery.
RESULTS
Nine patients with history of radiation therapy for nasopharyngeal carcinoma were included in our series. In all cases, partial or complete subjective improvement occurred.
CONCLUSIONS
In select cases, endoscopic sinus surgery could be of benefit in the treatment of delayed sinonasal complications of radiation therapy.
目的
放射治疗后的迟发性鼻-鼻窦并发症包括后鼻孔狭窄、放射性骨坏死、慢性鼻窦炎和鼻腔粘连。仅零星报道过此类疾病的手术治疗病例，且疗效结果不一。
方法和材料
我们对过去 10 年间在我院因放射治疗后迟发性鼻-鼻窦并发症而接受手术治疗的所有患者进行了前瞻性病例系列研究。纳入标准要求术后随访时间≥6 个月。纳入的患者被要求在术前和术后 6 个月分别完成 16 项 Sino-Nasal Outcome Test 问卷。
结果
本研究共纳入 9 例因鼻咽癌接受放射治疗的患者。所有患者均出现部分或完全的主观改善。
结论
在选择的病例中，鼻内镜鼻窦手术可能有助于治疗放射治疗后的迟发性鼻-鼻窦并发症。
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