哈尔明可逆转5-羟色胺2拮抗剂匹仑哌隆和酮色林对雌性大鼠脊柱前凸的抑制作用。

Harmine reverses the inhibition of lordosis by the 5-HT2 antagonists pirenperone and ketanserin in the female rat.

作者信息

Mendelson S D, Gorzalka B B

出版信息

Pharmacol Biochem Behav. 1986 Jul;25(1):111-5. doi: 10.1016/0091-3057(86)90239-x.

Abstract

The beta-carboline harmine was found to facilitate lordosis behavior in ovariectomized rats primed with estradiol benzoate. Moreover, harmine reversed the inhibition of lordosis by the serotonin type 2 (5-HT2) antagonists pirenperone and ketanserin in rats primed with estradiol benzoate and progesterone. These results suggest that harmine facilitates lordosis by enhancing activity at 5-HT2 receptors.

摘要

已发现β-咔啉骆驼蓬碱可促进用苯甲酸雌二醇预处理的去卵巢大鼠的脊柱前凸行为。此外，骆驼蓬碱可逆转血清素2型（5-HT2）拮抗剂匹仑哌隆和酮色林对用苯甲酸雌二醇和孕酮预处理的大鼠脊柱前凸的抑制作用。这些结果表明，骆驼蓬碱通过增强5-HT2受体的活性来促进脊柱前凸。