麦角新碱以时间依赖性方式抑制和促进雌性大鼠的脊柱前凸行为。

Methysergide inhibits and facilitates lordosis behavior in the female rat in a time-dependent manner.

作者信息

Mendelson S D, Gorzalka B B

出版信息

Neuropharmacology. 1986 Jul;25(7):749-55. doi: 10.1016/0028-3908(86)90091-2.

Abstract

Reports in the literature have indicated a facilitatory effect of the serotonin antagonist methysergide on lordosis behavior, suggesting an inhibitory role for serotonergic activity. In the present series of experiments, methysergide (7 mg/kg) was found to inhibit lordosis behavior 30 min after intraperitoneal administration to females, treated chronically with estradiol benzoate, or acutely with estradiol benzoate and progesterone. However, methysergide was found to facilitate lordosis behavior 200 and 300 min after administration to female rats treated acutely with estradiol benzoate. These data suggest a time-dependent inhibitory effect of methysergide, and are consistent with the hypothesis that the activity of serotonin type 2 receptors facilitates lordosis behavior in the female rat.

摘要

文献中的报告表明，血清素拮抗剂甲基麦角新碱对脊柱前凸行为有促进作用，提示血清素能活性具有抑制作用。在本系列实验中，发现给长期用苯甲酸雌二醇处理或急性用苯甲酸雌二醇和孕酮处理的雌性大鼠腹腔注射甲基麦角新碱（7毫克/千克）30分钟后，会抑制脊柱前凸行为。然而，发现给急性用苯甲酸雌二醇处理的雌性大鼠注射甲基麦角新碱后200和300分钟，会促进脊柱前凸行为。这些数据表明甲基麦角新碱具有时间依赖性抑制作用，并且与血清素2型受体的活性促进雌性大鼠脊柱前凸行为的假说一致。