来自个体献血核酸（ID-NAT）检测无反应性献血者的输血传播乙型肝炎病毒（HBV）感染。

Transfusion-transmitted hepatitis B virus (HBV) infection from an individual-donation nucleic acid (ID-NAT) non-reactive donor.

作者信息

O'Flaherty N, Ushiro-Lumb I, Pomeroy L, Ijaz S, Boland F, De Gascun C, Fitzgerald J, O'Riordan J

机构信息

Irish Blood Transfusion Service (IBTS), National Health Service Blood and Transplant, Dublin, Ireland.

National Virus Reference Laboratory (NVRL), University College Dublin (UCD), Dublin, Ireland.

出版信息

Vox Sang. 2018 Apr;113(3):300-303. doi: 10.1111/vox.12633. Epub 2018 Feb 14.

DOI:10.1111/vox.12633

PMID:29441587

Abstract

Lookback was initiated upon notification of an acute HBV infection in a repeat Irish donor, 108 days post-donation. The donation screened non-reactive by individual-donation nucleic acid testing (ID-NAT) using the Procleix Ultrio Elite multiplex assay and again when the archived sample was retested, but the discriminatory assay for HBV was reactive. The immunocompromised recipient of the implicated red cell component was tested 110 days post-transfusion, revealing a HBV DNA viral load of 470 IU/ml. Genotype C2 sequences identical across two regions of the HBV genome were found in samples from the donor and recipient.

摘要

在一名爱尔兰重复献血者捐献后108天被通报急性乙肝病毒（HBV）感染时启动了追溯调查。该捐献血液使用Procleix Ultrio Elite多重检测法进行的单份捐献核酸检测（ID-NAT）筛查结果为非反应性，存档样本重新检测时结果依然如此，但针对HBV的鉴别检测呈反应性。受影响红细胞成分的免疫功能低下受者在输血后110天接受检测，结果显示HBV DNA病毒载量为470 IU/ml。在来自捐献者和受者的样本中发现了HBV基因组两个区域完全相同的C2基因型序列。