中重度阻塞性睡眠呼吸暂停低通气综合征患者 IGF-1、补体 C3 和超氧化物歧化酶的变化。
Alterations of IGF-1, complement C3 and superoxide dismutase in patients with moderate-to-severe obstructive sleep apnea hypopnea syndrome.
机构信息
Department of Sleep Medicine Center, NanFang Hospital, Southern Medical University, Guangzhou 510515, PR China.
出版信息
Biomark Med. 2018 Mar;12(3):217-228. doi: 10.2217/bmm-2017-0099. Epub 2018 Feb 14.
AIM
To evaluate various biomarkers of metabolism, immunity and inflammation in obstructive sleep apnea hypopnea syndrome (OSAHS).
MATERIALS & METHODS: After overnight polysomnography, blood was collected from 292 OSAHS patients or healthy volunteers. Serum content of inflammatory, immune, metabolic biomarkers were investigated. In addition, the effects of 1-month continuous positive airway pressure (CPAP) were studied in moderate/severe OSAHS.
RESULTS
C3, serum total complement activity, superoxide dismutase, uric acid were significantly higher in moderate/severe OSAHS than that in no/mild OSAHS. In contrast, IGF-1 in moderate/severe OSAHS was lower than it in no/mild OSAHS, which was negative correlated with apnea-hypopnea index. Moreover, CPAP significantly decreased C3, meanwhile elevated IGF-1.
CONCLUSION
C3, serum total complement activity and superoxide dismutase were higher in moderate/severe OSAHS, while IGF-1 decreased. Elevated C3 and reduced IGF-1 in moderate/severe OSAHS may be reversed by CPAP.
目的
评估阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者的代谢、免疫和炎症的各种生物标志物。
材料与方法
对 292 例 OSAHS 患者或健康志愿者进行整夜多导睡眠图检查后，采集血液。检测血清中炎症、免疫和代谢生物标志物的含量。此外，还研究了 1 个月持续气道正压通气（CPAP）对中重度 OSAHS 的影响。
结果
中重度 OSAHS 患者的 C3、血清总补体活性、超氧化物歧化酶、尿酸明显高于无/轻度 OSAHS 患者。相反，中重度 OSAHS 患者的 IGF-1 低于无/轻度 OSAHS 患者，且与呼吸暂停低通气指数呈负相关。此外，CPAP 可显著降低 C3，同时升高 IGF-1。
结论
中重度 OSAHS 患者的 C3、血清总补体活性和超氧化物歧化酶升高，而 IGF-1 降低。CPAP 可逆转中重度 OSAHS 患者中升高的 C3 和降低的 IGF-1。
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