Youssef M M, El-Din Ems, AbuShady M M, El-Baroudy N R, Abd El Hamid T A, Armaneus A F, El Refay A S, Hussein J, Medhat D, Latif Y A
1 Department of Child Health, National Research Centre (NRC), Cairo, Egypt.
2 Department of Pediatric, Faculty of Medicine, Cairo University, Cairo, Egypt.
Hum Exp Toxicol. 2018 Nov;37(11):1180-1186. doi: 10.1177/0960327118758150. Epub 2018 Feb 14.
Bronchial asthma is one of the top disabling diseases in pediatrics. Limited research has been studied the association of the widely used plastic monomer bisphenol A (BPA) with childhood asthma.
To compare the levels of urinary BPA in asthmatic and control children and to investigate the implication of BPA among other risk factors for the development of asthma.
This case-control study included 97 children (45 asthmatic and 52 healthy controls) aged 3-8 years. Asthmatic children were diagnosed according to Global initiative for asthma (GINA) guidelines. Sociodemographic factors were assessed and urinary levels of BPA were determined in spot urine samples using high-performance liquid chromatography. The contribution of BPA among predictors for developing asthma was studied in asthmatic children.
Median total urinary BPA levels were significantly higher in asthmatic children than in control group (1.56 ng/mL in asthmatic children compared to 0.790 ng/mL in control group, p = 0.001). Children who had total urinary BPA levels >1.3 ng/mL were more likely to be asthmatic (odds ratio: 2.84, 95% confidence interval 1.22-6.59, p = 0.015). Multiple logistic regression analysis for predictors of asthma showed the importance of higher levels of BPA (>1.3 ng/mL) as a more significant predictor than passive smoking ( p = 0.006 for BPA categories vs. p = 0.049 for passive smoking).
Association of higher levels of urinary BPA with the diagnosis of asthma in children may indicate the potential risk of BPA exposure in the precipitation of bronchial asthma. Further clinical and biochemical research are needed to clarify the proper mechanism explaining this association.
支气管哮喘是儿科最致残的疾病之一。关于广泛使用的塑料单体双酚A（BPA）与儿童哮喘之间关联的研究有限。
比较哮喘儿童和对照儿童尿中双酚A的水平，并探讨双酚A在哮喘发生的其他危险因素中的作用。
本病例对照研究纳入了97名3至8岁的儿童（45名哮喘儿童和52名健康对照）。哮喘儿童根据全球哮喘防治创议（GINA）指南进行诊断。评估社会人口统计学因素，并使用高效液相色谱法测定即时尿样中双酚A的尿水平。在哮喘儿童中研究了双酚A在哮喘发生预测因素中的作用。
哮喘儿童尿中双酚A的总中位数水平显著高于对照组（哮喘儿童为1.56 ng/mL，而对照组为0.790 ng/mL，p = 0.001）。尿中双酚A总水平>1.3 ng/mL的儿童更易患哮喘（比值比：2.84，95%置信区间1.22 - 6.59，p = 0.015）。对哮喘预测因素的多因素逻辑回归分析表明，较高水平的双酚A（>1.3 ng/mL）作为比被动吸烟更显著的预测因素的重要性（双酚A类别p = 0.006，而被动吸烟p = 0.049）。
儿童尿中双酚A水平升高与哮喘诊断之间的关联可能表明双酚A暴露在支气管哮喘发病中的潜在风险。需要进一步的临床和生化研究来阐明解释这种关联的具体机制。
