İnce Tolga, Balcı Aylin, Yalçın Siddika Songül, Özkemahlı Gizem, Erkekoglu Pinar, Kocer-Gumusel Belma, Yurdakök Kadriye
Dokuz Eylul University, Faculty of Medicine, Department of Pediatrics, Social Pediatrics Unit, İnciraltı Mahallesi Mithatpaşa, Street No: 56, Balçova, 35340 İzmir, Turkey.
Hacettepe University, Faculty of Pharmacy, Department of Toxicology, Sihhiye, Ankara, Turkey.
J Pediatr Endocrinol Metab. 2018 Aug 28;31(8):829-836. doi: 10.1515/jpem-2018-0141.
Bisphenol-A (BPA) is one of the most abundantly produced chemicals globally. Concerns have been raised about BPA's possible role in the pathogenesis of type 1 diabetes mellitus (T1DM). The main aim of the current study was to evaluate the possible association between BPA exposure and T1DM. The second aim was to investigate children's possible BPA exposure routes in Turkey.
A total of 100 children aged between 5 and 18 years including 50 children with T1DM and 50 healthy children were included. Urinary BPA levels of all children were measured using high-performance liquid chromatography. Mothers of children enrolled in the study were also requested to complete a survey that included questions on the sociodemographic characteristics, medical history and possible BPA exposure routes of their children.
In the T1DM group, urinary BPA levels were slightly higher compared to the control group, but this difference was not significant (p=0.510). However, there was an inverse relationship between current urinary BPA levels and birth weight. It was found that the use of plastic kettles and the consumption of dairy products in plastic boxes significantly increased the urinary BPA concentrations in all subjects.
Although there was no significant association between urinary BPA levels and T1DM, we found an inverse relationship between current urinary BPA levels and birth weight. This finding might be important for prenatal exposure, and further prospective research must be conducted. Also, the use of plastic kettles, which has not been mentioned much in the literature before, was found to be an important exposure route for BPA.
双酚A（BPA）是全球产量最高的化学品之一。人们对BPA在1型糖尿病（T1DM）发病机制中可能发挥的作用表示担忧。本研究的主要目的是评估BPA暴露与T1DM之间的可能关联。第二个目的是调查土耳其儿童可能的BPA暴露途径。
共纳入100名5至18岁的儿童，其中包括50名T1DM儿童和50名健康儿童。使用高效液相色谱法测量所有儿童的尿BPA水平。还要求参与研究的儿童母亲完成一项调查问卷，其中包括有关其子女的社会人口统计学特征、病史和可能的BPA暴露途径的问题。
在T1DM组中，尿BPA水平与对照组相比略高，但差异不显著（p = 0.510）。然而，当前尿BPA水平与出生体重之间存在负相关关系。研究发现，使用塑料水壶和食用塑料盒包装的乳制品会显著增加所有受试者的尿BPA浓度。
虽然尿BPA水平与T1DM之间没有显著关联，但我们发现当前尿BPA水平与出生体重之间存在负相关关系。这一发现可能对产前暴露很重要，必须进行进一步的前瞻性研究。此外，塑料水壶的使用此前在文献中提及较少，但其被发现是BPA的一个重要暴露途径。
