Kozlu S, Sahin A, Calis S, Capan Y
Pharmazie. 2017 Oct 1;72(10):568-570. doi: 10.1691/ph.2017.7077.
An isocratic reversed phase HPLC method for the simultaneous determination of doxorubicine (DOX) and celecoxib (CXB) out of a nanoparticulate fixed dose combination (NanoFDC) was developed and validated. Linearity of the results was demonstrated from 1-11 μg/mL for both components. Lower limits of detection were determined as 7 ng/mL for DOX and 13 ng/mL for CXB. Total run time was approximately 15 min.
建立并验证了一种等度反相高效液相色谱法，用于同时测定纳米颗粒固定剂量复方制剂（NanoFDC）中的多柔比星（DOX）和塞来昔布（CXB）。两种成分的结果线性范围均为1 - 11μg/mL。多柔比星的检测下限为7 ng/mL，塞来昔布的检测下限为13 ng/mL。总运行时间约为15分钟。
