Chinh Nguyen Thuy, Trang Nguyen Thi Thu, Mai Tran Thi, Thanh Dinh Thi Mai, Trung Tran Huu, Trung Trinh Hoang, Quan Le Van, Hoa Nguyen Thi, Mao Can Van, Nghia Nguyen Trong, Hai Nguyen Thanh, Anh Tran Hong, Hung Tran Viet, Choy Jin-Ho, Loi Nguyen Van, Rajesh Baskaran, Hoang Thai
Institute for Tropical Technology, Vietnam Academy of Science and Technology, 18, Hoang Quoc Viet, Cau Giay, Ha Noi, 100000, Vietnam.
Department of Physiology, Vietnam Military Medical University, 60 Phung Hung, Ha Dong, Ha Noi, 100000, Vietnam.
J Nanosci Nanotechnol. 2018 Apr 1;18(4):2294-2303. doi: 10.1166/jnn.2018.14537.
This paper presents the results of zeta potential, water contact angle, atomic force microscopy image, in vitro solubility, and content of heavy metals in polylactic acid (PLA)/chitosan (CS) nanoparticles loading nifedipine. In addition, the In Vivo test of the PLA/CS nanoparticles loading nifedipine in the mice is also one of highlights of this work. The Zeta potential result shows that the charged surface of the PLA/CS nanoparticles loading nifedipine is neutral, negative or complex depending on nifedipine content. Nifedipine plays a role in increase of hydrophobic property, swelling degree and regular surface as well as decrease of surface rough of the nanoparticles. The PLA/CS/nifedipine nanoparticles are dissolved in the solutions with pH 6.8, pH 4.5 and pH 1.2. The In Vivo test of PLA/CS nanoparticles loading nifedipine on mice was evaluated by the change in diastolic pressure, systolic pressure, arterial pressure and heart rate. The obtained results confirm that the PLA/CS nanoparticles loading nifedipine is suitable to apply in the treatment of hypertension patients lately.
本文介绍了载有硝苯地平的聚乳酸（PLA）/壳聚糖（CS）纳米颗粒的zeta电位、水接触角、原子力显微镜图像、体外溶解度和重金属含量的结果。此外，载有硝苯地平的PLA/CS纳米颗粒在小鼠体内的试验也是这项工作的亮点之一。zeta电位结果表明，载有硝苯地平的PLA/CS纳米颗粒的带电表面根据硝苯地平含量呈中性、负性或复合性。硝苯地平在增加纳米颗粒的疏水性、溶胀度和表面规整性以及降低表面粗糙度方面发挥作用。PLA/CS/硝苯地平纳米颗粒可溶解于pH 6.8、pH 4.5和pH 1.2的溶液中。通过舒张压、收缩压、动脉压和心率的变化评估了载有硝苯地平的PLA/CS纳米颗粒对小鼠的体内试验。所得结果证实，载有硝苯地平的PLA/CS纳米颗粒适用于近期高血压患者的治疗。
