Lin Yong-Quan, Zhang Jing, Liu Shi-Jiang, Ye Hui
Department of Emergency, Yidu Central Hospital of Weifang, Qingzhou 262500, Shandong, China.
Department of Obstetrics, Shouguang People's Hospital, Shouguang 262700, Shandong, China.
J Nanosci Nanotechnol. 2018 Apr 1;18(4):2330-2336. doi: 10.1166/jnn.2018.14391.
In the following study, we describe the preparation and characterization of poly(ethylene glycol) (PEG) and biotin modified, doxorubicin (DOX) loaded silica nanoparticles (Dox/SLN-PEG-Biotin), which was employed as a drug delivery system for colon cancer therapy. The DOX/SLN-PEG-Biotin exhibited small particle size and low cytotoxicity in vitro. Moreover, the Dox releases from DOX/SLN-PEG-Biotin followed a redox-sensitive behavior. Biotin functionalized Dox/SLN-PEG-Biotin demonstrated tumor-targeted delivery of their payload, resulting in enhanced cellular uptake in HCT116 tumor cells and potentiated tumor accumulation in HCT116 tumor-bearing mice. In particular, in vivo anti-cancer assay confirmed that DOX/SLN-PEG-Biotin as a tumor-targeted delivery system exerted strong anti-cancer efficacy. Altogether, DOX chemotherapy using DOX/SLN-PEG-Biotin might be an effective strategy for improved treatment in colon cancer.
在以下研究中，我们描述了聚乙二醇（PEG）和生物素修饰的、负载阿霉素（DOX）的二氧化硅纳米颗粒（Dox/SLN-PEG-Biotin）的制备与表征，该纳米颗粒被用作结肠癌治疗的药物递送系统。DOX/SLN-PEG-Biotin在体外表现出小粒径和低细胞毒性。此外，DOX从DOX/SLN-PEG-Biotin中的释放呈现出氧化还原敏感行为。生物素功能化的Dox/SLN-PEG-Biotin显示出其载荷的肿瘤靶向递送，导致HCT116肿瘤细胞中的细胞摄取增强以及在荷HCT116肿瘤小鼠中的肿瘤蓄积增强。特别地，体内抗癌试验证实，DOX/SLN-PEG-Biotin作为肿瘤靶向递送系统发挥了强大的抗癌功效。总之，使用DOX/SLN-PEG-Biotin进行DOX化疗可能是改善结肠癌治疗的有效策略。
