Gozutok Melike, Basar Ahmet Ozan, Sasmazel Hilal Turkoglu
Department of Metallurgical and Materials Engineering, Atilim University, Incek, Golbasi, Ankara, 06836, Turkey.
J Nanosci Nanotechnol. 2018 Apr 1;18(4):2881-2891. doi: 10.1166/jnn.2018.14380.
In this study, a natural antibacterial substance chitosan was coated with/without potassium sorbate (KS) (0.8% (w/w) of KS, 8% (w/v) chitosan) onto the polypropylene (PP) film by using electrospinning technique to obtain novel antibacterial composite materials for various applications such as wound dressing, tissue engineering, drug delivery and food packaging. Atmospheric pressure plasma surface treatment was applied onto polypropylene films in order to increase its wettability thus enhancing the adhesion capacity of the films and the optimum CA value was determined as 42.75 ± 0.80°. Scanning Electron Microscope (SEM) and X-ray Photoelectron Spectroscopy (XPS) analyses were realized to observe the morphological changes and chemical properties of the samples, respectively. Contact angle measurements, tensile testing, oxygen and water vapor transmission rate analyses were performed to obtain wettability values, mechanical properties and WVTRs, respectively. The WVTR was increased by plasma treatment and addition of KS (from 14.264 ± 0.214% to 21.020 ± 0.659%). The desired antibacterial performance of the samples was assessed with Staphylococcus aureus and Escherichia coli by inhibition ratio calculation and disc diffusion assay. The highest inhibition ratios were found as 64% for S. aureus and 92% for E. coli for plasma-treated CS-KS-PP films.
在本研究中，通过静电纺丝技术将天然抗菌物质壳聚糖涂覆在聚丙烯（PP）薄膜上，有/无山梨酸钾（KS）（KS含量为0.8%（w/w），壳聚糖含量为8%（w/v）），以获得用于伤口敷料、组织工程、药物递送和食品包装等各种应用的新型抗菌复合材料。对聚丙烯薄膜进行大气压等离子体表面处理，以提高其润湿性，从而增强薄膜的粘附能力，确定最佳接触角（CA）值为42.75±0.80°。分别通过扫描电子显微镜（SEM）和X射线光电子能谱（XPS）分析来观察样品的形态变化和化学性质。进行接触角测量、拉伸测试、氧气和水蒸气透过率分析，分别以获得润湿性值、机械性能和水蒸气透过率（WVTR）。通过等离子体处理和添加KS，WVTR有所增加（从14.264±0.214%增加到21.020±0.659%）。通过抑制率计算和纸片扩散法，用金黄色葡萄球菌和大肠杆菌评估样品所需的抗菌性能。对于经等离子体处理的CS-KS-PP薄膜，发现对金黄色葡萄球菌的最高抑制率为64%，对大肠杆菌的最高抑制率为92%。
