Knupp Kelly, Koh Susan, Park Kristen
University of Colorado Denver and Children's Hospital Colorado, Aurora.
Neurol Clin Pract. 2012 Mar;2(1):40-47. doi: 10.1212/CPJ.0b013e31824c6cbd.
Epilepsy in children can be very different from epilepsy in adults, both in seizure type and epilepsy syndrome. The goal in treating children is seizure freedom, no treatment side effects, and function that is no different from the general population. In a significant percentage of patients, this goal remains unachievable, but many aspects of epilepsy are becoming clearer. This review will highlight 5 areas where progress is being made to achieve these goals in pediatric epilepsy. Specific research animal models are being developed to reflect the unique features of different pediatric epilepsies. As genetic syndromes are better identified, for some patients this has led to improved treatment. New advances in drug therapy have led to 3 new medications approved for children. More effective drug choices can now be recommended due to comparative drug trials and better overall care of children can be provided due to awareness of the comorbidities of epilepsy.
儿童癫痫在发作类型和癫痫综合征方面可能与成人癫痫有很大不同。治疗儿童癫痫的目标是无癫痫发作、无治疗副作用以及功能与普通人群无异。在相当比例的患者中，这一目标仍无法实现，但癫痫的许多方面正变得越来越清晰。本综述将重点介绍在实现儿童癫痫这些目标方面取得进展的5个领域。正在开发特定的研究动物模型以反映不同儿童癫痫的独特特征。随着遗传综合征得到更好的识别，对于一些患者来说，这带来了治疗的改善。药物治疗的新进展导致3种新药物获批用于儿童。由于进行了药物对比试验，现在可以推荐更有效的药物选择，并且由于对癫痫合并症的认识，可以为儿童提供更好的整体护理。
