早产儿接受低剂量静脉注射大豆油的两年神经发育和生长结局。
Two-Year Neurodevelopment and Growth Outcomes for Preterm Neonates Who Received Low-Dose Intravenous Soybean Oil.
机构信息
David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Neonatal Research Center of the UCLA Children's Discovery and Innovation Institute, Division of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
出版信息
JPEN J Parenter Enteral Nutr. 2018 Feb;42(2):352-360. doi: 10.1177/0148607116674482. Epub 2017 Dec 19.
BACKGROUND
In some studies, the dose of intravenous soybean oil (SO) has been associated with a decreased incidence of intestinal failure-associated liver disease. The effect of lipid sparing on neurodevelopment (ND) and growth remains unknown. This study investigated the impact of SO dose on ND and growth over the first 2 years of age in preterm neonates.
MATERIALS AND METHODS
This is a single-site prospective follow-up study. Neonates with a gestational age ≤29 weeks were randomized to low-dose (LOW) or standard-dose (CON) SO. Bayley Scales of Infant Development III and anthropometric measurements were collected at approximately 6, 12, and 24 months corrected gestational age.
RESULTS
Subjects were premature, with a mean (±SD) gestational age of 28 ± 1 and 27 ± 1 weeks (P = .3) for LOW and CON, respectively. Thirty subjects completed follow-up (LOW = 15, CON = 15). There were no differences for ND and growth outcomes when LOW was compared with CON, with the exception of a higher 12-month follow-up cognitive scaled score in the LOW group (P = .02).
CONCLUSION
A reduced SO dose did not adversely affect ND or growth in this cohort of preterm neonates. However, larger studies are needed to determine the long-term safety of SO dose reduction before this strategy can be adopted.
背景
在一些研究中，静脉注射大豆油（SO）的剂量与减少肠衰竭相关肝病（intestinal failure-associated liver disease，IFALD）的发生率有关。脂肪节约对神经发育（neurodevelopment，ND）和生长的影响仍不清楚。本研究旨在探讨早产儿静脉注射 SO 剂量对出生后 2 年内 ND 和生长的影响。
材料和方法
这是一项单中心前瞻性随访研究。将胎龄≤29 周的新生儿随机分为低剂量（LOW）组或标准剂量（CON）组。在出生后 6、12 和 24 个月校正胎龄时，采用贝利婴幼儿发展量表第三版（Bayley Scales of Infant Development III）和人体测量学方法进行评估。
结果
受试者均为早产儿，LOW 组和 CON 组的平均（±标准差）胎龄分别为 28 ± 1 和 27 ± 1 周（P =.3）。30 名受试者完成了随访（LOW = 15，CON = 15）。与 CON 组相比，LOW 组的 ND 和生长结局没有差异，除了 12 个月时的认知评分较高（P =.02）。
结论
在本队列早产儿中，减少 SO 剂量不会对 ND 或生长产生不良影响。然而，需要更大规模的研究来确定 SO 剂量减少的长期安全性，然后才能采用这种策略。
Zotero 插件