Plata F, Milon G, Garcia-Pons F, Marchal G
Ann Inst Pasteur Immunol. 1986 Jul-Aug;137D(1):47-61.
Trypanosoma cruzi is the causative agent of Chagas' disease in man, often leading to suppression of T lymphocyte functions; the present study thus considered the effects of infection by T. cruzi on T-dependent immune responses in a murine model, namely, the immune resistance to a syngeneic tumour and a delayed-type hypersensitivity reaction to sheep red blood cells (SRBC). In BALB.B mice infected with T. cruzi, the graft of syngeneic Gross murine leukaemia virus-induced tumour cells leads to an increased incidence of progressive subcutaneous tumours and development of lymphatic leukaemia. This decreased resistance to tumours correlates with a suppression of the generation of tumour-specific cytolytic T lymphocytes (CTL) from the pre-CTL stage. In contrast, clonal expansion and circulation of T cells detected through their ability to locally transfer a delayed-type hypersensitivity (DTH) reaction to SRBC remained normal in T. cruzi-infected mice. However, at the site of the DTH reaction, a decreased availability of phagocytes was observed in T. cruzi-infected mice.
克氏锥虫是人类恰加斯病的病原体，常导致T淋巴细胞功能受抑制；因此，本研究探讨了克氏锥虫感染对小鼠模型中T细胞依赖性免疫反应的影响，即对同基因肿瘤的免疫抗性以及对绵羊红细胞（SRBC）的迟发型超敏反应。在感染克氏锥虫的BALB.B小鼠中，同基因格罗斯小鼠白血病病毒诱导的肿瘤细胞移植会导致进行性皮下肿瘤的发生率增加以及淋巴白血病的发展。这种对肿瘤的抗性降低与从CTL前体细胞阶段开始的肿瘤特异性细胞毒性T淋巴细胞（CTL）生成受到抑制有关。相比之下，通过其局部转移对SRBC的迟发型超敏反应（DTH）的能力检测到的T细胞克隆扩增和循环在感染克氏锥虫的小鼠中仍保持正常。然而，在DTH反应部位，观察到感染克氏锥虫的小鼠中吞噬细胞的可用性降低。
