肺炎链球菌医院获得性肺炎感染株的全基因组序列分析。
Whole-Genome Sequence Analysis of Streptococcus pneumoniae Strains That Cause Hospital-Acquired Pneumonia Infections.
机构信息
Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan
Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan.
出版信息
J Clin Microbiol. 2018 Apr 25;56(5). doi: 10.1128/JCM.01822-17. Print 2018 May.
Abstract
colonizes the nasopharyngeal mucus in healthy individuals and can cause otitis media, pneumonia, and invasive pneumococcal diseases. In this study, we analyzed strains that caused 19 pneumonia episodes in long-term inpatients with severe underlying disease in a hospital during a period of 14 months (from January 2014 to February 2015). Serotyping and whole-genome sequencing analyses revealed that 18 of the 19 pneumonia cases were caused by strains belonging to 3 genetically distinct groups: clonal complex 9999 (CC9999), sequence type 282 (ST282), and ST166. The CC9999 and ST282 strains appeared to have emerged separately by a capsule switch from the pandemic PMEN 1 strain (Spain-ST81). After all the long-term inpatients were inoculated with the 23-valent pneumococcal polysaccharide vaccine, no other nosocomial pneumonia infections occurred until March 2016.
摘要
定植于健康个体的鼻咽黏液中，可引起中耳炎、肺炎和侵袭性肺炎球菌病。在这项研究中，我们分析了 14 个月（2014 年 1 月至 2015 年 2 月）期间一家医院中患有严重基础疾病的长期住院患者发生的 19 例肺炎的 菌株。血清分型和全基因组测序分析显示，19 例肺炎中有 18 例由 3 种遗传上不同的群的菌株引起：克隆复合体 9999（CC9999）、序列型 282（ST282）和 ST166。CC9999 和 ST282 菌株似乎是通过荚膜转换从大流行 PMEN 1 株（西班牙-ST81）中分别出现的。对所有长期住院患者接种 23 价肺炎球菌多糖疫苗后，直到 2016 年 3 月才发生其他医院获得性肺炎感染。
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