利用 CRISPR/Cas9 方法生成并鉴定 CYP2C11 基因敲除大鼠模型。
Generation and Characterization of a CYP2C11-Null Rat Model by Using the CRISPR/Cas9 Method.
机构信息
School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu, China (Y.W., L.Y., X.Z., D.S., C.W., K.W.); MtC BioPharma Co. Ltd., Nanjing, Jiangsu, China (M.S.); and Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, Jiangsu, China (D.G., H.W.)
School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu, China (Y.W., L.Y., X.Z., D.S., C.W., K.W.); MtC BioPharma Co. Ltd., Nanjing, Jiangsu, China (M.S.); and Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, Jiangsu, China (D.G., H.W.).
出版信息
Drug Metab Dispos. 2018 May;46(5):525-531. doi: 10.1124/dmd.117.078444. Epub 2018 Feb 14.
CYP2C11 is involved in the metabolism of many drugs in rats. To assess the roles of CYP2C11 in physiology and drug metabolism, a -null rat model was generated using the clustered
CYP2C11 参与大鼠体内许多药物的代谢。为了评估 CYP2C11 在生理学和药物代谢中的作用，使用成簇的方法生成了 CYP2C11-/- 大鼠模型。
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