Liu Juan, Liu Jianbin, Li Hai, Liu Liehua, Zheng Jing, Huang Zhimin, Cao Xiaopei, Xiao Haipeng, Li Yanbing
Endocrinology Department, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Centre for Eye Research Australia, Faculty of Medicine, Dentistry and Health Science, The University of Melbourne, East Melbourne, VIC 3002, Australia.
Int J Endocrinol. 2017;2017:6180904. doi: 10.1155/2017/6180904. Epub 2017 Dec 28.
To investigate the relationship between abdominal adipose tissue distribution, -cell function, and insulin sensitivity (IS) in a Chinese population.
One hundred and eighty-eight healthy subjects (healthy group), 239 with normal glucose, and 1~4 abnormal metabolic traits (metabolic dysfunction group, MD group) and 125 with hyperglycemia (hyperglycemia group) were studied. HOMA-IR, HOMA-B, Matsuda index, early- (I/G) and late-phase (I/G) insulin responses and the corresponding disposition indexes (DI) were calculated. The area of abdominal subcutaneous adipose tissue (ASAT) and visceral adipose tissue (VAT) was measured and the ratio of ASAT to VAT (SVR) was calculated.
SVR was correlated positively with Matsuda index in healthy, MD, and hyperglycemia groups, and inversely with HOMA-IR. SVR positively related with both early- and late-phase DI in the healthy group only. In the healthy group, the hyperbolas of I/G and I/G versus Matsuda index in the highest quarter of SVR were significantly right shifted compared to those in the lowest (both < 0.05).
In healthy adults, higher SVR was a protective factor for -cell function and IS, while in those with glucometabolic abnormality, higher SVR contributed to a relative better IS, indicating SVR is possible to be an early predicator of type 2 diabetes development.
探讨中国人群腹部脂肪组织分布、β细胞功能与胰岛素敏感性（IS）之间的关系。
对188名健康受试者（健康组）、239名血糖正常且有1至4项异常代谢特征者（代谢功能障碍组，MD组）以及125名高血糖患者（高血糖组）进行研究。计算稳态模型评估的胰岛素抵抗指数（HOMA-IR）、稳态模型评估的β细胞功能指数（HOMA-β）、松田指数、早期（I/G）和晚期（I/G）胰岛素反应以及相应的处置指数（DI）。测量腹部皮下脂肪组织（ASAT）和内脏脂肪组织（VAT）的面积，并计算ASAT与VAT的比值（SVR）。
在健康组、MD组和高血糖组中，SVR与松田指数呈正相关，与HOMA-IR呈负相关。仅在健康组中，SVR与早期和晚期DI均呈正相关。在健康组中，SVR最高四分位数组的I/G和I/G相对于松田指数的双曲线与最低四分位数组相比明显右移（均P<0.05）。
在健康成年人中，较高的SVR是β细胞功能和IS的保护因素，而在糖代谢异常者中，较高的SVR有助于相对较好的IS，表明SVR可能是2型糖尿病发生的早期预测指标。
