Beani J C, Amblard P, Reymond J L
Biochimie. 1986 Jun;68(6):905-12. doi: 10.1016/s0300-9084(86)80108-0.
Three phototherapeutic regimens with photosensitization are now used in dermatology: PUVA (psoralen + UVA), TUV (crude coaltar + UV), PRT (phototherapy with hematoporphyrin derivative). The efficiency of PUVA and TUV is well known in several dermatoses. PRT is now being tested experimentally. For TUV, the lack of a standardized regimen does not allow a clear-cut evaluation of the therapy. For PUVA, late side-effects, particularly carcinogenicity have to be considered. To improve efficiency and minimize the side-effects of PUVA some procedures, such as association with retinoïds, pharmaco-kinetic studies for individual adaptation of the therapeutic regimen and the use of new less mutagenic psoralens are helpful. The persistent phototoxicity following treatments with hematoporphyrin derivative constitutes the major side-effect observed, for this phototherapy.
补骨脂素加长波紫外线（PUVA）、粗煤焦油加紫外线（TUV）、血卟啉衍生物光疗（PRT）。补骨脂素加长波紫外线及粗煤焦油加紫外线疗法对多种皮肤病的疗效已为人熟知。血卟啉衍生物光疗目前正在进行实验测试。对于粗煤焦油加紫外线疗法，由于缺乏标准化方案，无法对该疗法进行明确评估。对于补骨脂素加长波紫外线疗法，必须考虑其晚期副作用，尤其是致癌性。为提高疗效并将补骨脂素加长波紫外线疗法的副作用降至最低，一些措施，如与维甲酸联合使用、进行药代动力学研究以根据个体情况调整治疗方案以及使用新的低致突变性补骨脂素等，均有帮助。血卟啉衍生物治疗后持续存在的光毒性是该光疗观察到的主要副作用。
