Aboutaleb Nahid, Zarrati Mitra, Cheshmazar Elhameh, Shoormasti Raheleh Shokouhi, Razmpoosh Elham, Nasirinezhad Farinas
Physiology Research Center and Physiology Department, Faculty of Medicine Iran University of Medical Sciences, Tehran, Iran.
Faculty of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Med J Islam Repub Iran. 2017 Dec 16;31:81. doi: 10.14196/mjiri.31.81. eCollection 2017.
Oxidative stress in obese people is an important pathogenic mechanism of an obesity-associated metabolic syndrome. We evaluated the association between circulating leptin levels with biomarkers of oxidative stress in overweight and obese participants. This study was performed on 189 overweight and obese people aged 18-60 years old. Serum leptin, superoxide dismutase (SOD), high-sensitivity C-reactive protein (hs-CRP), homocysteine (Hcy), thiobarbituric acid reactive substances (TBARS) and amyloid A (SAA) concentrations were measured. Pearson correlation and multiple linear regressions were used to assess the relationships. We found that among the biomarkers of oxidative stress and inflammation in participants, serum hs-CRP and SAA were positively correlated with BMI (β=0.003, P<0.001 and β=7.83, P<0.001, respectively). This relationship remained significant even after controlling other oxidative stress and inflammatory indicators (β=0.003, p<0.001 for hs-CRP), but this association disappeared for SAA. In addition, serum hs-CRP was positively correlated with leptin (β=0.001, p=0.003). Regression analysis showed that there was no association between serum Hcy, SAA, TBARS and SOD with serum leptin concentrations Overall, the current study demonstrated that serum hs-CRP and SAA levels were independently correlated with BMI. Furthermore, serum hs-CRP was positively correlated with leptin. Focusing on such strategies may lead to promises for alleviating obesity and its co-morbidities.
肥胖人群的氧化应激是肥胖相关代谢综合征的重要致病机制。我们评估了超重和肥胖参与者循环瘦素水平与氧化应激生物标志物之间的关联。本研究对189名年龄在18至60岁的超重和肥胖人群进行。测量了血清瘦素、超氧化物歧化酶（SOD）、高敏C反应蛋白（hs-CRP）、同型半胱氨酸（Hcy）、硫代巴比妥酸反应物质（TBARS）和淀粉样蛋白A（SAA）的浓度。采用Pearson相关性分析和多元线性回归来评估这些关系。我们发现，在参与者的氧化应激和炎症生物标志物中，血清hs-CRP和SAA与BMI呈正相关（β=0.003，P<0.001和β=7.83，P<0.001）。即使在控制了其他氧化应激和炎症指标后，这种关系仍然显著（hs-CRP的β=0.003，p<0.001），但SAA的这种关联消失了。此外，血清hs-CRP与瘦素呈正相关（β=0.001，p=0.003）。回归分析表明，血清Hcy、SAA、TBARS和SOD与血清瘦素浓度之间没有关联。总体而言，当前研究表明血清hs-CRP和SAA水平与BMI独立相关。此外，血清hs-CRP与瘦素呈正相关。关注此类策略可能为减轻肥胖及其合并症带来希望。
