Division of Pediatric Gastroenterology, Hepatology and Nutrition, Nationwide Children's Hospital, Columbus, Ohio, USA.
Nutr Clin Pract. 2018 Aug;33(4):493-509. doi: 10.1002/ncp.10011. Epub 2018 Feb 15.
Enteral nutrition (EN) for the treatment of Crohn's disease (CD) involves administration of a liquid nutrition product, administered orally or through tube feeding, while excluding typical dietary components. It is a safe and effective, but largely underused, therapy in the United States as a treatment for CD. EN is a particularly attractive option for pediatric CD as it avoids side effects of corticosteroids, improves growth, and may have a higher likelihood of achieving mucosal healing than some traditional medications. However, there are multiple real and perceived barriers to its use among providers. A comprehensive approach to addressing these barriers to EN may result in its increased use. This paper reviews the literature on the efficacy of EN, methods of utilization, and potential barriers and solutions to those barriers.
肠内营养(EN)治疗克罗恩病(CD)包括给予液体营养产品,经口或通过管饲给予,同时排除典型的饮食成分。在美国,EN 是一种安全有效的治疗方法,但很大程度上未被充分应用于 CD 的治疗。EN 作为小儿 CD 的治疗方法特别有吸引力,因为它可避免皮质类固醇的副作用,促进生长,并且与某些传统药物相比,更有可能实现黏膜愈合。然而,提供者在使用 EN 方面存在多种实际和感知到的障碍。全面解决这些 EN 使用障碍的方法可能会增加其使用。本文综述了 EN 的疗效、使用方法以及这些障碍的潜在障碍和解决方案的文献。