Department of Biotechnology, University of Kashmir, Srinagar 190006, Jammu and Kashmir, India.
Biol Chem. 2018 May 24;399(6):525-547. doi: 10.1515/hsz-2017-0329.
Small RNAs govern almost every biological process in eukaryotes associating with the Argonaute (AGO) proteins to form the RNA-induced silencing complex (mRISC). AGO proteins constitute the core of RISCs with different members having variety of protein-binding partners and biochemical properties. This review focuses on the AGO subfamily of the AGOs that are ubiquitously expressed and are associated with small RNAs. The structure, function and role of the AGO proteins in the cell is discussed in detail.
小 RNA 调控真核生物中的几乎所有生物学过程，与 Argonaute（AGO）蛋白结合形成 RNA 诱导沉默复合物（miRISC）。AGO 蛋白是 RISCs 的核心，不同成员具有多种蛋白结合伙伴和生化特性。本综述重点介绍普遍表达并与小 RNA 相关的 AGO 蛋白的 AGO 亚家族。详细讨论了 AGO 蛋白在细胞中的结构、功能和作用。
