DNA位点D4S10及相关的亨廷顿氏病基因定位于4p16----p15。
Mapping of the DNA locus D4S10 and the linked Huntington's disease gene to 4p16----p15.
作者信息
Zabel B U, Naylor S L, Sakaguchi A Y, Gusella J F
出版信息
Cytogenet Cell Genet. 1986;42(4):187-90. doi: 10.1159/000132276.
An anonymous DNA fragment (G8) detects two restriction fragment length polymorphic alleles (RFLPs) called D4S10 in HindIII-digested human genomic DNA. This segment had been assigned to chromosome 4 and shows close linkage to the Huntington's disease gene. With in situ hybridization, we mapped D4S10 to the terminal region of the short arm of chromosome 4, localizing the Huntington's disease gene to bands 4p16----p15. This information may prove useful for the development of strategies to clone the Huntington's disease gene.
一个匿名的DNA片段（G8）在经HindIII消化的人类基因组DNA中检测到两个称为D4S10的限制性片段长度多态性等位基因（RFLP）。该片段已被定位到4号染色体，并显示与亨廷顿病基因紧密连锁。通过原位杂交，我们将D4S10定位到4号染色体短臂的末端区域，从而将亨廷顿病基因定位到4p16----p15带。这一信息可能对克隆亨廷顿病基因的策略的开发有用。
Zotero 插件