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一项比较酮咯酸与曲安奈德注射剂用于成人扳机指的随机对照试验。

A randomized controlled trial comparing ketorolac and triamcinolone injections in adults with trigger digits.

作者信息

Leow Mabel Qi He, Hay Aik Siew Robyn, Ng Shu Li, Choudhury Muntasir Mannan, Li Huihua, McGrouther Duncan Angus, Tay Shian Chao

机构信息

1 Biomechanics Laboratory, Singapore General Hospital, Singapore.

2 Department of Hand Surgery, Singapore General Hospital, Singapore.

出版信息

J Hand Surg Eur Vol. 2018 Nov;43(9):936-941. doi: 10.1177/1753193418756808. Epub 2018 Feb 15.

Abstract

We assessed the efficacy of ketorolac trometamol injections compared with triamcinolone acetonide injections in trigger digits. Patients with trigger digits were randomized to receive either ketorolac or triamcinolone. They were followed up at 3, 6, 12 and 24 weeks, and monitored for resolution of triggering, pain and total active motion. One hundred and twenty-one patients with single trigger digits were recruited (59 ketorolac, 62 triamcinolone). At 6 weeks, 54% of patients in the triamcinolone group had complete resolution of trigger, whereas no patients in the ketorolac group had resolution. At 12 weeks, 58% of patients in the triamcinolone group had complete resolution of trigger compared with 6.7% in the ketorolac group. At 24 weeks, both groups had comparable rates of resolution at 26% and 25%, respectively. Patients in the triamcinolone group had significantly better resolution of pain at 3, 6 and 12 weeks. But at 24 weeks, there was no significant difference in pain between both groups. Significantly less flexion deformity was reported at 3 weeks and 6 weeks in the triamcinolone group. In the short term, ketorolac was less effective in relieving symptoms of trigger digit than triamcinolone. Level of evidence: I.

摘要

我们评估了曲安奈德注射液与酮咯酸氨丁三醇注射液治疗扳机指的疗效。将扳机指患者随机分为两组,分别接受酮咯酸或曲安奈德治疗。在3周、6周、12周和24周对患者进行随访,观察扳机症状、疼痛及总主动活动度的缓解情况。共纳入121名单发扳机指患者(酮咯酸组59例,曲安奈德组62例)。6周时,曲安奈德组54%的患者扳机症状完全缓解,而酮咯酸组无患者缓解。12周时,曲安奈德组58%的患者扳机症状完全缓解,酮咯酸组为6.7%。24周时,两组的缓解率相当,分别为26%和25%。曲安奈德组患者在3周、6周和12周时疼痛缓解情况明显更好。但在24周时,两组疼痛无显著差异。曲安奈德组在3周和6周时报告的屈曲畸形明显更少。短期内,酮咯酸在缓解扳机指症状方面比曲安奈德效果更差。证据级别:I级。

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