University of Kentucky HealthCare, Department of Pharmacy Services, 800 Rose Street, Room H110, Lexington, KY 40536-0293, USA; University of Kentucky College of Pharmacy, Department of Pharmacy Practice and Science, 789 South Limestone Street, Lexington, KY 40536, USA.
Nebraska Medicine, Department of Pharmaceutical and Nutrition Care, 987400 Nebraska Medical Center, Omaha, NE 68198-7400, USA.
Am J Surg. 2018 Aug;216(2):351-358. doi: 10.1016/j.amjsurg.2018.01.040. Epub 2018 Feb 12.
Enterocutaneous fistulae (ECF) and enteroatmospheric fistulae (EAF) are difficult complications that primarily arise after abdominal surgical procedures. Development of an ECF or EAF carries significant mortality and morbidity. Effective management of patients with these disease states requires a multidisciplinary approach, which includes surgical, pharmacotherapeutic, and nutritional interventions. This review focuses on the medical and nutritional management of ECF/EAF, providing background on drug agents and nutritional strategies that may be helpful in reducing effluent volume, optimizing fistula healing, and maintaining nutritional health.
肠外瘘（ECF）和肠内瘘（EAF）是腹部手术后常见的严重并发症。ECF 或 EAF 的发生会显著增加死亡率和发病率。对这些疾病状态患者的有效管理需要多学科方法，包括手术、药物治疗和营养干预。本文重点介绍 ECF/EAF 的医疗和营养管理，提供可能有助于减少流出量、优化瘘管愈合和维持营养健康的药物和营养策略的背景知识。
