University of Oslo Centre for Lifespan Changes in Brain and Cognition (UiO), Department of Psychology, Harald Schelderups Hus, Forskningsveien 3A, N-0373 Oslo, Norway.
University of Oslo Centre for Lifespan Changes in Brain and Cognition (UiO), Department of Psychology, Harald Schelderups Hus, Forskningsveien 3A, N-0373 Oslo, Norway.
Eur Psychiatry. 2018 Apr;50:47-56. doi: 10.1016/j.eurpsy.2017.12.006. Epub 2018 Feb 12.
The main objective of "Lifebrain" is to identify the determinants of brain, cognitive and mental (BCM) health at different stages of life. By integrating, harmonising and enriching major European neuroimaging studies across the life span, we will merge fine-grained BCM health measures of more than 5000 individuals. Longitudinal brain imaging, genetic and health data are available for a major part, as well as cognitive and mental health measures for the broader cohorts, exceeding 27,000 examinations in total. By linking these data to other databases and biobanks, including birth registries, national and regional archives, and by enriching them with a new online data collection and novel measures, we will address the risk factors and protective factors of BCM health. We will identify pathways through which risk and protective factors work and their moderators. Exploiting existing European infrastructures and initiatives, we hope to make major conceptual, methodological and analytical contributions towards large integrative cohorts and their efficient exploitation. We will thus provide novel information on BCM health maintenance, as well as the onset and course of BCM disorders. This will lay a foundation for earlier diagnosis of brain disorders, aberrant development and decline of BCM health, and translate into future preventive and therapeutic strategies. Aiming to improve clinical practice and public health we will work with stakeholders and health authorities, and thus provide the evidence base for prevention and intervention.
“Lifebrain”的主要目标是确定不同生命阶段大脑、认知和心理（BCM）健康的决定因素。通过整合、协调和丰富整个生命周期的主要欧洲神经影像学研究，我们将合并超过 5000 个人的精细 BCM 健康测量值。大部分研究都有纵向脑成像、遗传和健康数据，以及更广泛队列的认知和心理健康测量值，总共超过 27000 次检查。通过将这些数据与其他数据库和生物库（包括出生登记处、国家和地区档案）联系起来，并通过新的在线数据收集和新措施对其进行丰富，我们将研究 BCM 健康的风险因素和保护因素。我们将确定风险和保护因素发挥作用的途径及其调节剂。利用现有的欧洲基础设施和倡议，我们希望为大型综合队列及其有效利用做出重大的概念、方法和分析贡献。因此，我们将提供有关 BCM 健康维持以及 BCM 障碍的发生和病程的新信息。这将为大脑障碍的早期诊断、BCM 健康的异常发展和衰退奠定基础，并转化为未来的预防和治疗策略。我们旨在通过与利益相关者和卫生当局合作来改善临床实践和公共卫生，从而为预防和干预提供证据基础。
