Diensthuber M, Stöver T
Klinik für Hals-Nasen-Ohrenheilkunde, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt/M., Deutschland.
HNO. 2018 Mar;66(3):179-187. doi: 10.1007/s00106-017-0466-1.
Despite impressive technical progress in the field of conventional hearing aids and implantable hearing systems, the hopes for the treatment of inner ear diseases such as hearing loss and tinnitus have become increasingly directed toward regenerative therapeutic approaches. This review discusses the currently most promising strategies for hair cell regeneration in the inner ear to treat hearing loss, including stem cell-based, gene transfer-based, and pharmacological interventions. Furthermore, previous milestones and ground-breaking work in this scientific field are identified. After many years of basic research, the first clinical trials with a regenerative therapeutic approach for hearing-impaired patients were recently initiated. Although there is still a long and bumpy road ahead until a true breakthrough is achieved, it seems more realistic than ever that regenerative therapies for the inner ear will find their way into clinical practice.
尽管传统助听器和植入式听力系统领域取得了令人瞩目的技术进步，但治疗听力损失和耳鸣等内耳疾病的希望越来越多地指向再生治疗方法。本综述讨论了目前用于内耳毛细胞再生以治疗听力损失的最有前景的策略，包括基于干细胞的、基于基因转移的和药物干预。此外，还确定了该科学领域以前的里程碑和开创性工作。经过多年的基础研究，最近启动了针对听力受损患者的再生治疗方法的首批临床试验。尽管在实现真正的突破之前仍有很长的崎岖道路要走，但内耳再生疗法进入临床实践似乎比以往任何时候都更现实。
